1.

学位論文
学位
1. Molecular Structure of Mucus Glycoprotein in Human Colon
Kubo, Kohmei
出版情報: pp.1-27,  1991-03-20. 
URL: http://hdl.handle.net/10129/5237
概要: 授与大学:弘前大学; 学位種類:医学博士; 授与年月日:平成3年3月20日; 学位記番号:医博甲846第号
2.

学位論文
学位
2. Comparative Studies on Proteodermatan Sulfate of Bovine Gastrointestinal Tract
Kawasaki, Hitoshi
出版情報: pp.1-23,  1991-03-20. 
URL: http://hdl.handle.net/10129/5241
概要: 授与大学:弘前大学; 学位種類:医学博士; 授与年月日:平成3年3月20日; 学位記番号:医博甲第847号
3.

学位論文
学位
3. Age-related changes in chemical structure and affinity for hydroxyapatite of glycosaminoglycan chains from small proteoglycan of human yellow ligament
Takeda, Yusuke
出版情報: pp.1-32,  1993-03-24. 
URL: http://hdl.handle.net/10129/5252
概要: 授与大学:弘前大学; 学位種類:博士（医学）; 授与年月日:平成5年3月24日; 学位記番号:医博甲第960号
4.

学位論文
学位
4. Negative Regulation of Erythroid Transcription Factor p45 NF-E2 during Megakaryocytic Differentiation of Human Megakaryoblastic Cell Lines Induced with Phorbol Ester Stimulation
土岐, 力
出版情報: pp.1-17,  1997-09-16. 
URL: http://hdl.handle.net/10129/5273
概要: 授与大学:弘前大学; 学位種類:博士（医学）; 授与年月日:平成9年9月16日; 学位記番号:医博乙第782号
5.

学位論文
学位
5. Expression of Cadherins in Astrocytic Tumors
浅野, 研一郎
出版情報: pp.1-17,  1998-03-25. 
URL: http://hdl.handle.net/10129/5275
概要: 授与大学:弘前大学; 学位種類:博士（医学）; 授与年月日:平成10年3月25日; 学位記番号:医博甲第1225号
6.

学位論文
学位
6. Higher prevalence of platelet-activating factor acetylhydrolase deficiency gene among stroke survivors
平元, 周
出版情報: pp.1-11,  1997-03-26. 
URL: http://hdl.handle.net/10129/6059
概要: 授与大学:弘前大学; 学位種類:博士（医学）; 授与年月:平成9年3月26日; 学位記番号:医博乙第760号
7.

学位論文
学位
7. ALS-associated protein FIG4 is localized in Pick and Lewy bodies, and also neuronal nuclear inclusions, in polyglutamine and intranuclear inclusion body diseases
Kon, Tomoya
出版情報: Neuropathology.  34  pp.19-26,  2014-02.  Wiley
URL: http://hdl.handle.net/10129/5329
概要: http://onlinelibrary.wiley.com/doi/10.1111/neup.12056/citedby
8.

学位論文
学位
8. Morphological and electrophysiological changes in intratelencephalic-type pyramidal neurons in the motor cortex of a rat model of levodopa-induced dyskinesia
Ueno, Tatsuya
出版情報: Neurobiology of Disease.  64  pp.142-149,  2014-04.  Elsevier
URL: http://hdl.handle.net/10129/5330
概要: http://www.sciencedirect.com/science/article/pii/S0969996113003586
9.

学位論文
学位
9. Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model
Nishijima, Haruo
出版情報: Movement Disorders.  29  pp.336-343,  2014-03.  Wiley
URL: http://hdl.handle.net/10129/5331
概要: http://onlinelibrary.wiley.com/doi/10.1002/mds.25826/abstract
10.

学位論文
学位
10. Tumor Microenvironment and RIG-I Signaling Molecules in Epstein Barr Virus-positive and -negative Classical Hodgkin Lymphoma of the Elderly
Sato, Tsugumi
出版情報: Journal of Clinical and Experimental Hematopathology.  54  pp.75-84,  2014-06.  日本リンパ網内系学会
URL: http://hdl.handle.net/10129/5332
概要: 本文はJ-Stageより転載。
11.

学位論文
学位
11. Non-invasive quantification of liver damage by a novel application for statistical analysis of ultrasound signals
Yakoshi, Yuta
出版情報: 弘前医学.  65  pp.199-208,  2014-09-30.  弘前大学大学院医学研究科・弘前医学会
URL: http://hdl.handle.net/10129/5333
12.

学位論文
学位
12. Invadopodia are essential in transurothelial invasion during the muscle invasion of bladder cancer cells
Imanishi, Kengo
出版情報: Molecular Medicine Reports.  9  pp.2159-2165,  2014-06.  Spandidos Publications
URL: http://hdl.handle.net/10129/5334
概要: http://www.spandidos-publications.com/mmr/9/6/2159
13.

学位論文
学位
13. Core2 O-glycan-expressing prostate cancer cells are resistant to NK cell immunity resistant to NK cell immunity
Okamoto, Teppei
出版情報: Molecular Medicine Reports.  7  pp.359-364,  2013-02.  Spandidos Publications
URL: http://hdl.handle.net/10129/5335
概要: http://www.spandidos-publications.com/mmr/7/2/359
14.

学位論文
学位
14. Extravasation during bladder cancer metastasis requires cortactin‑mediated invadopodia formation
Tokui, Noriko
出版情報: Molecular Medicine Reports.  9  pp.1142-1146,  2014-04.  Spandidos Publications
URL: http://hdl.handle.net/10129/5336
概要: http://www.spandidos-publications.com/mmr/9/4/1142
15.

学位論文
学位
15. Inhibitory effects of aromatase inhibitor on estrogen receptor-alpha positive ovarian cancer in mice
Hirokawa, Hachidai
出版情報: Journal of Ovarian Research.  7  2014-01.  BioMed Central
URL: http://hdl.handle.net/10129/5337
概要: http://www.ovarianresearch.com/content/7/1/4
16.

学位論文
学位
16. Periosteum-derived cells respond to mechanical stretch and activate Wnt and BMP signaling pathways
Itoh, Ryohei
出版情報: Biomedical research.  35  pp.69-79,  2014-02.  Biomedical Research Foundation
URL: http://hdl.handle.net/10129/5338
概要: https://www.jstage.jst.go.jp/article/biomedres/35/1/35_69/_article
17.

学位論文
学位
17. Role of type I- and type II-interferon in expression of melanoma differentiation-associated gene-5 in HSC-3 oral squamous carcinoma cells
Kon, Takao
出版情報: Biomedical research.  35  pp.9-16,  2014-02.  Biomedical Research Foundation
URL: http://hdl.handle.net/10129/5339
概要: https://www.jstage.jst.go.jp/article/biomedres/35/1/35_9/_article
18.

学位論文
学位
18. Cognitive function and number of teeth in a community-dwelling population in Japan
Saito, Yuki
出版情報: Annals of General Psychiatry.  2013  2013-06.  BioMed Central
URL: http://hdl.handle.net/10129/5340
概要: http://www.annals-general-psychiatry.com/content/12/1/20
19.

学位論文
学位
19. Production of Growth-related Oncogene Protein-α in A Human Oral Squamous Cell Carcinoma Cell Line Stimulated with Tumor Necrosis Factor-α: Role in Tumor Angiogenesis and Tumor Proliferation
Narita, Norihiko
出版情報: 弘前医学.  65  pp.147-155,  2014.  弘前大学大学院医学研究科・弘前医学会
URL: http://hdl.handle.net/10129/5341
20.

学位論文
学位
20. Clinical features and predictors of lethal ventricular tachyarrhythmias after cardiac resynchronization therapy for primary prevention of sudden cardiac death
Ishida, Yuji
出版情報: Journal of Arrhythmia.  30  pp.367-371,  2014.  Elsevier
URL: http://hdl.handle.net/10129/5342
21.

学位論文
学位
21. Low serum eicosapentaenoic acid level is a risk for ventricular arrhythmia in patients with acute myocardial infarction: a possible link to J-waves
Endo, Tomohide
出版情報: Heart Vessels, 29(6), 2014, p.847-854.  29  pp.847-854,  2013-11.  Springer
URL: http://hdl.handle.net/10129/5343
概要: http://link.springer.com/article/10.1007/s00380-013-0435-x
22.

学位論文
学位
22. Coupling factor 6 attenuates CXCR4 expression through the HIF-1α and c-Src pathways and promotes endothelial apoptosis and inflammation
Suzuki, Akiko
出版情報: Hypertension Research.  37  pp.708-715,  2014.  Nature Publishing
URL: http://hdl.handle.net/10129/5344
概要: http://www.nature.com/hr/journal/vaop/ncurrent/full/hr201465a.html
23.

学位論文
学位
23. Prognostic impact of atrial fibrillation in patients with acute myocardial infarction
Tateyama, Shunta
出版情報: Journal of Arrhythmia, 30(6), 2014, p.460-465.  30  pp.460-465,  2014.  Elsevier
URL: http://hdl.handle.net/10129/5345
概要: http://www.sciencedirect.com/science/article/pii/S1880427614000076
24.

学位論文
学位
24. CD34-negative mesenchymal stem-like cells may act as the cellular origin of human aortic valve calcification
Nomura, Anan
出版情報: Biochemical and Biophysical Research Communications.  440  pp.780-785,  2013-11.  Elsevier
URL: http://hdl.handle.net/10129/5346
概要: http://www.sciencedirect.com/science/article/pii/S0006291X13016574
25.

学位論文
学位
25. Change with advancing age in the control of lower limbs during jump-landing in adolescents: a 5-year prospective study
Sasaki, Shizuka
出版情報: Journal of Orthopaedic Science.  18  pp.774-781,  2013-09-01.  Springer
URL: http://hdl.handle.net/10129/5347
概要: http://link.springer.com/article/10.1007/s00776-013-0420-3
26.

学位論文
学位
26. Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament
Harada, Yoshifumi
出版情報: Biochemical and Biophysical Research Communications.  443  pp.1014-1020,  2014-01.  Elsevier
URL: http://hdl.handle.net/10129/5348
概要: http://www.sciencedirect.com/science/article/pii/S0006291X13021517
27.

学位論文
学位
27. HbAlcと動脈の硬さの関連に関する研究 : 岩木健康増進プロジェクトでの横断研究と追跡研究
有賀, 玲子
出版情報: 体力・栄養・免疫学雑誌.  2014.  体力・栄養・免疫学会
URL: http://hdl.handle.net/10129/5349
28.

学位論文
学位
28. Relationship between Exhaled Hydrogen and Human Neutrophil Function in the Japanese General Population
谷川, 涼子
出版情報: 弘前医学.  65  pp.138-146,  2014.  弘前大学大学院医学研究科・弘前医学会
URL: http://hdl.handle.net/10129/5350
29.

学位論文
学位
29. 一般住民における血圧と動脈壁硬化度の関係に関する研究 : 岩木健康増進プロジェクトにおける6年間の追跡研究
小西, 裕之
出版情報: 体力・栄養・免疫学雑誌.  2014.  体力・栄養・免疫学会
URL: http://hdl.handle.net/10129/5355
30.

学位論文
学位
30. Physical condition during periodization for 3 months in female ekiden runners
Yoneda, Katsuro
出版情報: 体力・栄養・免疫学雑誌.  2014.  体力・栄養・免疫学会
URL: http://hdl.handle.net/10129/5358
31.

学位論文
学位
31. Exclusion of Influences of ARMS2 Polymorphisms on the Central Visual Field in Retinitis Pigmentosa.
Masahara, Hidetaka
出版情報: Ophthalmologica.  231  pp.51-57,  2013-12.  Karger
URL: http://hdl.handle.net/10129/5362
概要: http://www.karger.com/Article/FullText/355093 © 2014 S. Karger AG, Basel
32.

学位論文
学位
32. Clinical application of immunocytochemical detection of ALK rearrangement on cytology slides for detection or screening of lung adenocarcinoma
Tanaka, Hisashi
出版情報: Lung Cancer.  80  pp.289-292,  2013-06.  Elsevier
URL: http://hdl.handle.net/10129/5363
概要: http://www.sciencedirect.com/science/article/pii/S0169500213001116
33.

学位論文
学位
33. Impaired pulmonary function in the university students who had asthma in childhood
Tanaka, Yoshihito
出版情報: 弘前医学.  65  pp.128-137,  2014.  弘前大学大学院医学研究科・弘前医学会
URL: http://hdl.handle.net/10129/5364
34.

学位論文
学位
34. Regulation of corticotropin-releasing factor and urocortin 2/3 mRNA by leptin in hypothalamic N39 cells
Yamagata, Satoshi
出版情報: Peptides.  50  pp.1-4,  2013-12.  Elsevier
URL: http://hdl.handle.net/10129/5365
35.

学位論文
学位
35. Involvement of Nurr-1/Nur77 in corticotropin-releasing factor/urocortin1-induced tyrosinase-related protein 1 gene transcription in human melanoma HMV-II cells
Watanuki, Yutaka
出版情報: Molecular and Cellular Endocrinology.  370  pp.42-51,  2013-05.  Elsevier
URL: http://hdl.handle.net/10129/5366
概要: http://www.sciencedirect.com/science/article/pii/S0303720713000452
36.

学位論文
学位
36. Expression of Natural Cytotoxicity Receptors on Peritoneal Fluid Natural Killer Cell and Cytokine Production by Peritoneal Fluid Natural Killer Cell in Women with Endometriosis
Funamizu, Ayano
出版情報: American Journal of Reproductive Immunology.  71  pp.359-367,  2014-04.  Wiley
URL: http://hdl.handle.net/10129/5367
概要: http://onlinelibrary.wiley.com/doi/10.1111/aji.12206/abstract
37.

学位論文
学位
37. A Morphometric Investigation of Pulmonary Sympathetic Innervation in Nitrofen-Induced Congenital Diaphragmatic Hernia Rats
Kobayashi, Tamotsu
出版情報: 弘前医学.  65  pp.74-81,  2014-04-15.  弘前大学大学院医学研究科・弘前医学会
URL: http://hdl.handle.net/10129/5368
38.

学位論文
学位
38. Investigation of bispectral index asymmetry in patients with cerebral infarction
Sawada, Masahiro
出版情報: 弘前医学.  65  pp.156-163,  2014.  弘前大学大学院医学研究科・弘前医学会
URL: http://hdl.handle.net/10129/5369
39.

学位論文
学位
39. Physical condition in female judoists over 20-days strengthening and tapering periods
Oyamada, Kazuyuki
出版情報: 体力・栄養・免疫学雑誌.  2014.  体力・栄養・免疫学会
URL: http://hdl.handle.net/10129/5372
40.

学位論文
学位
40. Proton Pump Inhibitor Treatment Decreases the Incidence of Upper Gastrointestinal Disorders in Elderly Japanese Patients Treated with NSAIDs
Sakamoto, Yuki
出版情報: Internal Medicine.  53  pp.1107-1111,  2014-07-01.  the Japanese Society of Internal Medicine
URL: http://hdl.handle.net/10129/5373
概要: https://www.jstage.jst.go.jp/article/internalmedicine/53/11/53_53.2159/_article
41.

学位論文
学位
41. Sex-specific effects of subjective memory complaints with respect to cognitive impairment or depressive symptoms
Tomita, Tetsu
出版情報: Psychiatry and Clinical Neurosciences.  68  pp.176-181,  2014-03.  Wiley
URL: http://hdl.handle.net/10129/5374
概要: http://onlinelibrary.wiley.com/doi/10.1111/pcn.12102/abstract
42.

学位論文
学位
42. Carnosic acid suppresses the production of amyloid-β 1–42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells
Meng, Pengfei
出版情報: Neuroscience Research.  75  pp.94-102,  2013-02.  Elsevier
URL: http://hdl.handle.net/10129/5375
概要: http://www.sciencedirect.com/science/article/pii/S0168010212002349
43.

学位論文
学位
43. Relation Between the Persistence of an Abnormal Muscle Response and the Long-term Clinical Course After Microvascular Decompression for Hemifacial Spasm
Tobishima, Hana ; Hatayama, Toru ; Ohkuma, Hiroki
出版情報: Neurologia medico-chirurgica.  54  pp.474-482,  2014-06.  日本脳神経外科学会
URL: http://hdl.handle.net/10129/5106
概要: Neurologia medico chirurgica(日本脳神経外科学会)掲載論文。J-STAGEより本文転載。
44.

学位論文
学位
44. Corrected right ventricular end-diastolic volume and initial distribution volume of glucose correlate with cardiac output after cardiac surgery
Saito, Junichi ; Ishihara, Hironori ; Hashiba, Eiji ; Okawa, Hirobumi ; Kudo, Tomoyuki ; Sawada, Masahiro ; Tsubo, Toshihito ; Hirota, Kazuyoshi
出版情報: Journal of anesthesia.  27  pp.512-520,  2013-08.  Springer
URL: http://hdl.handle.net/10129/5107
概要: 雑誌掲載本文：http://link.springer.com/article/10.1007/s00540-013-1558-z
45.

学位論文
学位
45. Diets of obese and non-obese older subjects
Yaegashi, Yukoh ; Satoh, Atsuko ; Kudoh, Hideaki ; Lee, Sangun ; Kitamiy, Chiaki ; Butler, James P. ; Sasaki, Hidetada
出版情報: Health.  5  pp.361-363,  2013-03.  Scientific Research
URL: http://hdl.handle.net/10129/5108
概要: Aim: To compare diets between obese and non-obese in healthy older subjects. Methods: Forty-five obese and eighty-seven non-obese older subjects were recruited and their habitual factors that may contribute to obesity were … assessed. Intakes of food by food-group in the obesity and non-obesity groups were checked using a visual type presentation of model nutriational balance chart (MNBC). Results: Average intake ratio of food relative to ideal food intake was significantly higher in the obesity group than the non-obesity group. The relationship of obesity and exercise or habitual activities was not significant. Conclusion: Food intake is a primary factor of obesity but regular exercise or habitual activities is not a key factor for obesity in older subjects. Since exercise habit is difficult to achieve in older subjects, particularly those who are obese, food control using the present visualtype MNBC would be one strategy forthe management of obesity.<br />Open Access Journal 続きを見る
46.

学位論文
学位
46. Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit
Naraoka, Masato ; Munakata, Akira ; Matsuda, Naoya ; Shimamura, Norihito ; Ohkuma, Hiroki
出版情報: Translational Stroke Research.  4  pp.368-374,  2013-01.  Springer
URL: http://hdl.handle.net/10129/5109
概要: The Rho/Rho-kinase pathway is considered important in the pathogenesis of sustained smooth muscle cell contraction durin … g cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). The aims of this study were to investigate whether combination treatment, with pitavastatin as an inhibitor of RhoA and fasudil as an inhibitor of Rho-kinase, prevents the cerebral vasospasm. SAH was simulated using the double-hemorrhage rabbit model, and pitavastatin, or fasudil, or both (combination treatment) were administrated. The basilar artery (BA) cross-sectional area only in the combination treatment group was statistically larger than in the SAH group (p < 0.05). BA Rho-kinase, as measured by ELISA, was statistically reduced only in the combination treatment group compared with the SAH group (p < 0.05). In the other two treatment groups, pitavastatin or fasudil treatment group showed larger BA cross-sectional areas and lower value for BA Rho-kinase, but there were no statistically significant differences compared with the SAH group. The expression of endothelial nitric oxide synthase (eNOS), evaluated by immunohistochemistry in the pitavastatin group and the combination group, was higher than in the SAH group. Results indicate that combination treatment could extensively prevent cerebral vasospasm due to the synergic effect of combining pitavastatin and fasudil on the Rho/Rho-kinase pathway and on eNOS.<br />Open Access Article 続きを見る
47.

学位論文
学位
47. The relationship between muscle damage and reactive oxygen species production capability after judo exercise
Kudou, Hisashi ; Yaegaki, Makoto ; Takahashi, Ippei ; Umeda, Takashi ; Sawada, Kaori ; Okubo, Noriyuki ; Yamamoto, Yousuke ; Nakaji, Shigeyuki
出版情報: 弘前医学.  64  2014.  弘前医学会
URL: http://hdl.handle.net/10129/5110
48.

学位論文
学位
48. Effects of cholesterol alterations are mediated via G-protein-related pathways in outer hair cells
Nagaki, Takahiko ; Kakehata, Seiji ; Kitani, Rei ; Abe, Takahisa ; Shinkawa, Hideichi
出版情報: Pflügers Archiv.  465  pp.1041-1049,  2013-02-17.  Springer
URL: http://hdl.handle.net/10129/5111
49.

学位論文
学位
49. Accuracy of Image-Free Computer Navigated Total Knee Arthroplasty Is Not Compromised in Severely Deformed Varus Knees
Maniwa, Keiichiro ; Ishibashi, Yasuyuki ; Yamamoto, Yuji ; Inoue, Ryo ; Otsuka, Hironori
出版情報: The Journal of Arthroplasty.  28  pp.802-806,  2013-05.  Elsevier
URL: http://hdl.handle.net/10129/5112
50.

学位論文
学位
50. Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments
Chin, Shunfu ; Furukawa, Ken-Ichi ; Ono, Atsushi ; Asari, Toru ; Harada, Yoshifumi ; Wada, Kanichiro ; Tanaka, Toshihiro ; Inaba, Wataru ; Mizukami, Hiroki ; Motomura, Shigeru ; Yagihashi, Soroku ; Ishibashi, Yasuyuki
出版情報: Biochemical and biophysical research communications.  436  pp.698-704,  2013-06.  Elsevier
URL: http://hdl.handle.net/10129/5113
概要: Mesenchymal stem cells (MSCs) have been isolated from various tissues and used for elucidating the pathogenesis of numer … ous diseases. In our previous in vitro study, we showed the existence of MSCs in human spinal ligaments and hypothesized that these MSCs contributed to the pathogenesis of ossification of spinal ligaments. The purpose of this study was to use immunohistochemical techniques to analyze the localization of MSCs in ossified human spinal ligaments in situ. Ossified (OLF) or non-ossified ligamentum flavum (non-OLF) samples from the thoracic vertebra were obtained from patients who had undergone posterior spinal surgery. Serial sections were prepared from paraffin-embedded samples, and double immunofluorescence staining was performed using antibodies against markers for MSCs (CD73, CD90 and CD105), endothelial cells (CD31), pericytes (α-smooth muscle actin), and chondrocytes (S100). Immunolocalization of MSCs was observed in the perivascular area and collagenous matrix in spinal ligaments. Markers for MSCs and pericytes were co-expressed in the perivascular area. Compared with non-OLF, OLF had a large amount of neovascularization in the fragmented ligament matrix, and a high accumulation of MSCs around blood vessels. The prevalence of MSCs in OLF within collagenous matrix was significantly higher than that in non-OLF. Chondrocytes near the ossification front in OLF also presented expression of MSC markers. MSCs may contribute to the ectopic ossification process of OLF through endochondral ossification. 続きを見る
51.

学位論文
学位
51. Evaluation of locomotive disability using loco-check: a cross-sectional study in the Japanese general population
Sasaki, Eiji ; Ishibashi, Yasuyuki ; Tsuda, Eiichi ; Ono, Atsushi ; Yamamoto, Yuji ; Inoue, Ryo ; Takahashi, Ippei ; Umeda, Takashi ; Nakaji, Shigeyuki
出版情報: Journal of orthopaedic science.  18  pp.121-129,  2013-01.  Springer
URL: http://hdl.handle.net/10129/5114
概要: 論文の全文は掲載不可
52.

学位論文
学位
52. Reduction of paraoxonase-1 activity may contribute the qualitative impairment of HDL particles in patients with type 2 diabetes
Murakami, Hiroshi ; Tanabe, Jutaro ; Tamasawa, Naoki ; Matsumura, Koki ; Yamashita, Maki ; Matsuki, Kota ; Matsui, Jun ; Suda, Toshihiro
出版情報: Diabetes research and clinical practice.  99  pp.30-38,  2013-01.  Elsevier
URL: http://hdl.handle.net/10129/5115
概要: 博士論文の本文は掲載不可
53.

学位論文
学位
53. Intraoperative navigation evaluation of tibial translation after resection of anterior cruciate ligament remnants
前田, 周吾
出版情報: Arthroscopy: The Journal of Arthroscopy and Related Surgery.  27  pp.1203-1210,  2015-03-24. 
URL: http://hdl.handle.net/10129/5620
概要: 出版社版本文リンクhttp://www.sciencedirect.com/science/article/pii/S0749806311003665
54.

学位論文
学位
54. Parental bonding and attitudes toward suicide among medical college students in Japan
Hashimoto, Kojiro
出版情報: Neuropsychiatric Disease and Treatment.  10  pp.2015-2020,  2015-03-24.  Dovepress
URL: http://hdl.handle.net/10129/5588
概要: 出版社版リンクhttp://www.dovepress.com/getfile.php?fileID=22147
55.

学位論文
学位
55. MUC5AC-Negative Phenotype is Correlated with Poor Patient Prognosis of Pancreas Head Ductal Carcinoma.
Sakuraba, Shingo
出版情報: 2015-03-24. 
URL: http://hdl.handle.net/10129/5589
概要: 弘前医学66(1)2015、p.28-37に掲載
56.

学位論文
学位
56. LW6, a HIF-1 Inhibitor, Selectively Induces Apoptosis in Hypoxic Cells through Depolarization of Mitochondria in A549 Human Lung Cancer Cells
Sato, Mariko
出版情報: 2015-03-24. 
URL: http://hdl.handle.net/10129/5590
概要: 出版社版本文リンクMolecular Medicine Reports　12(3),2015http://www.spandidos-publications.com/mmr/12/3/3462
57.

学位論文
学位
57. Decreased expression of carbonyl reductase 1 promotes ovarian cancer growth and proliferation
Osawa, Yuki
出版情報: International journal of oncology.  pp.1-7,  2015-03-24.  Spandidos Publications
URL: http://hdl.handle.net/10129/5591
概要: 出版社版本文リンクhttp://www.spandidos-publications.com/ijo/46/3/1252
58.

学位論文
学位
58. 4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression
Tamura, Ryosuke
出版情報: Journal of Ovarian Research.  7  2015-03-24.  BioMed Central
URL: http://hdl.handle.net/10129/5592
59.

学位論文
学位
59. The level of RECQL1 expression is a prognostic factor for epithelial ovarian cancer
Matsushita, Yoko
出版情報: Journal of Ovarian Research.  7  2015-03-24.  BioMed Central
URL: http://hdl.handle.net/10129/5593
概要: 出版社版本文リンクhttp://www.ovarianresearch.com/content/7/1/107
60.

学位論文
学位
60. The prophylactic effects of a traditional Japanese medicine, goshajinkigan, on paclitaxel-induced peripheral neuropathy and its mechanism of action
Matsumura, Yukiko
出版情報: Molecular Pain.  10  2015-03-24.  BioMed Central Ltd
URL: http://hdl.handle.net/10129/5594
61.

学位論文
学位
61. Role of protein kinase C in acetylcholine-induced Ca2+ influx under enhanced phospholipase C-δ1
Murakami, Kazuo
出版情報: 弘前医学.  66  pp.22-27,  2015-03-24. 
URL: http://hdl.handle.net/10129/5595
概要: 冠攣縮性狭心症患者の皮膚線維芽細胞においてphospholipase C(PLC)-δ1活性は亢進しており、PLC-δ1過剰発現マウスでは冠攣縮が誘発されることを報告した。今回我々はPLC-δ1過剰発現下で、アセチルコリン誘発性カルシウム流 … 入におけるprotein kinase C(PKC)の役割についてhuman embryonic kidney 293細胞を用いて検討した。アセチルコリン誘発性カルシウム流入はPLC-δ1過剰発現並びにPKCの抑制により優位に増加し，PKCの活性化により減少した。ニフェジピン存在下でのアセチルコリン誘発性カルシウム流入もPLC-δ1過剰発現並びにPKCの抑制により増加した。PKCはアセチルコリン誘発性カルシウム流入に対して負に作用し，ニフェジピン投与の影響をほとんど受けないことが示唆された。<br />http://repository.ul.hirosaki-u.ac.jp/dspace/handle/10129/5559 続きを見る
62.

学位論文
学位
62. Relationship between self-reported sleep quality and metabolic syndrome in general population
Okubo, Noriyuki
出版情報: BMC Public Health.  14  2015-03-24.  BioMed Central Ltd.
URL: http://hdl.handle.net/10129/5596
63.

学位論文
学位
63. Influence of atherosclerosis-related biomarkers on neutrophil basal reactive oxygen species production in the general population
Wada, Naoko
出版情報: 2015-03-24. 
URL: http://hdl.handle.net/10129/5598
64.

学位論文
学位
64. Dietary patterns and schizophrenia : a comparison with healthy controls.
Tsuruga, Koji
出版情報: Neuropsychiatric Disease and Treatment.  11  pp.1120-,  2015-03-24. 
URL: http://hdl.handle.net/10129/5605
概要: 出版社版本文リンクhttp://www.dovepress.com/getfile.php?fileID=24755
65.

学位論文
学位
65. Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells
清野, 浩子
出版情報: Biomedical Research.  36  pp.89-96,  2015-03-24. 
URL: http://hdl.handle.net/10129/5606
66.

学位論文
学位
66. Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats
稲葉, 渉
出版情報: European Journal of Pharmacology.  691  pp.297-306,  2015-03-24. 
URL: http://hdl.handle.net/10129/5607
概要: 出版社版本文リンクhttp://www.sciencedirect.com/science/article/pii/S0014299912006243
67.

学位論文
学位
67. Inhibition of heat shock protein 90 decreases ACTH production and cell proliferation in AtT-20 cells
杉山, 綾
出版情報: Pituitary.  18  pp.542-553,  2015-03-24. 
URL: http://hdl.handle.net/10129/5608
概要: 出版社版本文リンクhttp://link.springer.com/article/10.1007%2Fs11102-014-0607-4
68.

学位論文
学位
68. Isolated low HDL-Cholesterol in Japanese patients with type 2 diabetes
松村, 功貴
出版情報: Diabetology International.  2015  2015-03-24. 
URL: http://hdl.handle.net/10129/5609
概要: 出版社版本文リンクhttp://dx.doi.org/10.1007/s13340-014-0200-0
69.

学位論文
学位
69. Inhibitory effects of SOM230 on adrenocorticotropic hormone production and corticotroph tumor cell proliferation in vitro and in vivo
村澤, 真吾
出版情報: Molecular and Cellular Endocrinology.  394  pp.37-46,  2015-03-24. 
URL: http://hdl.handle.net/10129/5610
概要: 出版社版本文リンクhttp://www.sciencedirect.com/science/article/pii/S0303720714002056
70.

学位論文
学位
70. Relationship between occupational stress and depression among psychiatric nurses in Japan
吉澤, 佳織
出版情報: 2015-03-24. 
URL: http://hdl.handle.net/10129/5612
71.

学位論文
学位
71. Association Between Body Composition and Pulmonary Function by Measuring Resting Metabolic Rate Using Indirect Calorimetry in Chronic Respiratory Disease Patients
漆坂, 真弓
出版情報: 弘前医学.  2015-03-24. 
URL: http://hdl.handle.net/10129/5613
72.

学位論文
学位
72. Plasma Ropivacaine Concentrations after Ultrasound-guided Rectus Sheath Block in Patients Undergoing Lower Abdominal Surgery
和田, 盛人
出版情報: Anesthesia and Analgesia.  114  pp.230-232,  2015-03-24. 
URL: http://hdl.handle.net/10129/5616
73.

学位論文
学位
73. Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition
叶, 鵬
出版情報: Molecular and Cellular Biology.  34  pp.3421-3434,  2015-03-24. 
URL: http://hdl.handle.net/10129/5618
74.

学位論文
学位
74. Serum tri- and tetra-antennary N-glycan is a potential predictive biomarker for castration-resistant prostate cancer.
石橋, 祐介
出版情報: Prostate.  74  pp.1521-1529,  2015-03-24. 
URL: http://hdl.handle.net/10129/5619
概要: 出版社版本文リンクhttp://onlinelibrary.wiley.com/doi/10.1002/pros.22869/abstract
75.

学位論文
学位
75. Islet amyloid with macrophage migration correlates with augmented b-cell deficits in type 2 diabetic patients
Kamata, Kosuke ; Mizukami, Hiroki ; Inaba, Wataru ; Tsuboi, Kentaro ; Tateishi, Yoshinori ; Yoshida, Taro ; Yagihashi, Soroku
出版情報: Amyloid.  21  pp.191-201,  2014-09.  Informa healthcare
URL: http://hdl.handle.net/10129/5472
概要: Aims: Islet amyloid is a hallmark in type 2 diabetic subjects, but its implication in clinical features and development of islet pathology is still unclear.Methods: From 118 autopsy cases with type 2 diabetes, 26 cases with … islet amyloid deposition (DA+) were selected. Twenty diabetic subjects without obvious amyloid deposition (DA ) matched for the age and diabetes duration and 20 non-diabetic subjects (ND) served for comparison. We examined the severity of amyloid deposition and its relationships with population of endocrine cells, expression of cell damage markers or macrophage infiltration. Correlation of clinical profile with islet pathology was also sought on the subset of the investigated patients.Results: b-Cell volume density was nearly 40% less in DA+ and 20% less in DA when compared to ND. Severity of amyloid deposition correlated with reduced volume densities of b-cell and a-cell, and increased body mass index (BMI), but not with duration of diabetes, age or HbA1c. Amyloid-rich islets contained an increased number of macrophages mixed with b-cells with oxidative stress-related DNA damage, characterized by gH2AX expression, and suppressed (pro)insulin mRNA expression.Conclusions: In Japanese type 2 diabetic patients, islet amyloid was more common with severe b-cell loss and high BMI, associated with macrophage infiltration. 続きを見る
76.

学位論文
学位
76. Role of oxidized LDL and lectin-like oxidized LDL receptor-1 in cerebral vasospasm after subarachnoid hemorrhage
Mastuda, Naoya
出版情報: Journal of neurosurgery.  121  pp.621-630,  2014-09.  American Association of Neurological Surgeons
URL: http://hdl.handle.net/10129/5474
概要: 掲載誌本文：http://thejns.org/doi/abs/10.3171/2014.5.JNS132140
77.

学位論文
学位
77. Gene Alterations Involving the CRLF2-JAK Pathway and Recurrent Gene Deletions in Down Syndrome-Associated Acute Lymphoblastic Leukemia in Japan
Isamu, Hanada
出版情報: Genes, chromosomes & cance.  53  pp.902-910,  2014-11.  John Wiley & Sons, Inc.
URL: http://hdl.handle.net/10129/5475
概要: 出版社版本文：http://onlinelibrary.wiley.com/doi/10.1002/gcc.22201/abstract
78.

学位論文
学位
78. Invasive micropapillary carcinoma of the extrahepatic bile duct and its malignant potential
Yoshizawa, Tadashi
出版情報: Oncology Reports.  32  pp.1355-1361,  2014-08.  Spandidos Publications
URL: http://hdl.handle.net/10129/5476
概要: Invasive micropapillary carcinoma (IMPC) was originally described as a distinctive type of invasive carcinoma in the bre … ast, but it has not been recognized as a histological type of the extrahepatic bile duct cancer. The present study demonstrated clinicopathological features and patient prognosis of IMPC. We examined histological reviews of 93 consecutive cases of the extrahepatic bile duct cancer and identified 13 cases which included IMPC component. The component of IMPC ranged from 5 to 60% of the primary tumor tissue, which was mainly detected at the invasive front of the tumor. Of the 13 cases, 12 (92.3%) carcinomas with IMPC showed lymph node metastasis more frequently compared to conventional adenocarcinoma (39.2%, P<0.001). Presence of IMPC component was significantly associated with poor overall survival (P=0.003). In conclusion, extrahepatic bile duct carcinoma with IMPC component showed significant lymphatic invasion, lymph node metastasis, and resulted in poor prognosis.<br />本文リンク：http://www.spandidos-publications.com/or/32/4/1355 続きを見る
79.

学位論文
学位
79. Vimentin intermediate filament and plectin provide a scaffold for invadopodia, facilitating cancer cell invasion and extravasation for metastasis
Yoneyama, Mihoko
出版情報: European Journal of Cell Biology.  93  pp.157-169,  2014-04.  Elsevier
URL: http://hdl.handle.net/10129/5477
概要: To investigate the molecular mechanisms of cancer metastasis, we have isolated a high-metastatic bladder cancer cell sub … population from a low-metastatic cell line by using an in vivo selection system. Cells in the subpopulation showed a high ability to form invadopodia, the filamentous actin (F-actin)-based membrane protrusions that play an essential role in cancer cell invasion. Analysis of the gene expression profile revealed that the expression of an intermediate filament (IF) protein, vimentin and a cytoskeletal linker protein, plectin was up-regulated in the high-metastatic subpopulation compared with the low metastatic cell line. Here we report a novel role of vimentin IF and plectin in metastasis. In invasive bladder cancer cells, the vimentin IF-plectin-invadopodia F-actin link was formed. Disruption of this link severely impaired invadopodia formation, reducing the capacities of extracellular matrix degradation, transendothelial migration and metastasis. In addition, the vimentin assembly into the filaments was required for invadopodia formation. Our results suggest that plectin anchoring invadopodia to vimentin IF scaffolds and stabilizes invadopodia, which is a critical molecular process for cancer cell invasion and extravasation for metastasis.<br />掲載誌本文リンク：http://www.sciencedirect.com/science/article/pii/S017193351400048X 続きを見る
80.

学位論文
学位
80. Attenuation of collagen-induced arthritis in mice by salmon proteoglycan
Yoshimura, Sayuri
出版情報: BioMed Research International.  2014  2014-05.  Hindawi Publishing Corporation
URL: http://hdl.handle.net/10129/5478
概要: Rheumatoid arthritis (RA) is a serious autoimmune disease caused by chronic inflammation of connective tissues. The basi … c principle of RA treatment is aimed to reduce joint inflammation. Our previous studies demonstrated that salmon cartilage proteoglycan (PG) suppresses excess inflammation in different mouse inflammatory diseases. In this study, we investigated the prophylactic effect of PG on the progression of RA using an experimental mouse model, collagen-induced arthritis (CIA). Clinical and histological severity of CIA was attenuated by daily oral administration of PG. In the joints of PG-administered mice, infiltration of macrophages and neutrophils and also osteoclast accumulation were limited. In comparison to nonadministered mice, anti-collagen antibodies in the sera of PG-administered mice did not alter. On the other hand, local expression of interleukin-17A (IL-17A), IL-6, IL-1β, interferon-γ (IFN-γ), C-C chemokine ligand 2 (CCL2), C-X-C chemokine ligand 1 (CXCL1), and CXCL2 in the joints of PG-administered mice decreased. Moreover, in the response of type II collagen- (CII-) restimulation ex vivo, IL-17A and IFN-γ production by splenocytes from PG-administered mice was less than that of control mice. These data suggested that daily ingested PG attenuated CIA pathogenesis by modulating immune response of splenocytes to CII stimulation and local production inflammatory cytokines and chemokines in the joints.<br />掲載誌本文：http://www.hindawi.com/journals/bmri/2014/406453/ 続きを見る
81.

学位論文
学位
81. Uptake of a fluorescent L-glucose derivative 2-NBDLG into three-dimensionally accumulating insulinoma cells in a phloretin-sensitive manner
Sasaki, Ayako
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5858
概要: 掲載誌Human Cell, 29(1), p.37-45, 2016\nhttp://link.springer.com/article/10.1007/s13577-015-0125-3
82.

学位論文
学位
82. The low level of understanding of depression among patients treated with antidepressants: a survey of 424 outpatients in Japan
Kudo, Syuhei
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5859
概要: 掲載誌Neuropsychiatric Disease and Treatment, 2015(11), p.2811-2816, 2015http://dx.doi.org/10.2147/NDT.S93657
83.

学位論文
学位
83. Phenotypic characterization of early biliary tract carcinomas proposes two carcinogenesis pathways.
Haga, Toshihiro
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5860
概要: 掲載誌弘前医学, 67(1), p.28-38, 2016
84.

学位論文
学位
84. Clinicopathological significance of gastric poorly differentiated medullary carcinoma
Hirai, Hideaki
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5861
概要: 掲載誌Biomedical Research (Tokyo), 37(2), p.77-84, 2016http://doi.org/10.2220/biomedres.37.77
85.

学位論文
学位
85. Antitumor effects of the hyaluronan inhibitor, 4-methylumbelliferone, on pancreatic cancer
Yoshida, Eri
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5862
概要: 掲載誌Oncology Letters, 12(4), 2337-2344, 2016
86.

学位論文
学位
86. Detection of core2 β-1,6-N-Acetylglucosaminyltransferase in post-digital rectal examination urine is a reliable indicator for extracapsular extension of prostate cancer.
Kojima, Yuta
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5863
概要: 掲載誌PLoS ONE, Sep. 21, 2015http://dx.doi.org/10.1371/journal.pone.0138520
87.

学位論文
学位
87. The implication of aortic calcification on persistent hypertension after laparoscopic adrenalectomy in patients with primary aldosteronism
Fujita, Naoki
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5864
概要: 掲載誌International Journal of Urology, 23(5), p.412-417, 2016http://onlinelibrary.wiley.com/doi/10.1111/iju.13060/abstract
88.

学位論文
学位
88. Gene therapy for ovarian cancer using carbonyl reductase 1 DNA with a polyamidoamine dendrimer in mouse models.
Kobayashi, Asami
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5865
概要: 掲載誌Cancer Gene Therapy, 23, p.24-28, 2016http://www.nature.com/cgt/journal/v23/n1/full/cgt201561a.html
89.

学位論文
学位
89. Inhibitory effect of carbonyl reductase 1 on ovarian cancer growth via tumor necrosis factor receptor signaling
Miura, Rie
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5866
概要: 掲載誌International Journal of Oncology, 47(6), p.2173-2180, 2015https://www.spandidos-publications.com/ijo/47/6/2173?text=fulltext
90.

学位論文
学位
90. The pretreatment neutrophil‑to‑lymphocyte ratio predicts therapeutic response to radiation therapy and concurrent chemoradiation therapy in uterine cervical cancer
Mizunuma, Makito
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5867
概要: 掲載誌International Journal of Clinical Oncology, 20(5), p.989-996, 2015http://link.springer.com/article/10.1007%2Fs10147-015-0807-6
91.

学位論文
学位
91. Serum pentosidine concentration is associated with radiographic severity of lumbar spondylosis in a general Japanese population
Chiba, Daisuke
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5868
概要: 掲載誌Journal of Bone and Mineral Metabolism, 35(1), p.65-72, 2017
92.

学位論文
学位
92. The Knee injury and Osteoarthritis Outcome Score reflects the severity of knee osteoarthritis better than the revised Knee Society Score in a general Japanese population
Oishi, Kazuki
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5869
概要: 掲載誌The Knee, 23(1), p.35-42, 2016
93.

学位論文
学位
93. Eviprostat has an identical effect compared to pollen extract (Cernilton) in patients with chronic prostatitis/chronic pelvic pain syndrome: A randomized, prospective study
Iwamura, Hiromichi
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5870
概要: 掲載誌BMC Urology, 201515:120, 2015
94.

学位論文
学位
94. Core 2 β-1, 6-N-acetylglucosaminyltransferase-1 expression in prostate biopsy specimen is an indicator of prostate cancer aggressiveness
Sato, Tendo
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5871
概要: 掲載誌Biochemical and Biophysical Research Communications, 170(1), p.150-156, 2016http://www.sciencedirect.com/science/article/pii/S0006291X16300110
95.

学位論文
学位
95. I-branching N-acetylglucosaminyltransferase regulates prostate cancer invasiveness by enhancing α5β1 integrin signaling
Mikami, Jotaro
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5872
概要: 掲載誌Cancer Science, 107(3), p.359-368, 2015http://onlinelibrary.wiley.com/doi/10.1111/cas.12859/abstract
96.

学位論文
学位
96. Association of Sex Hormones with Neutrophil Function in the General Population
Sato, Satoshi
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5874
概要: 掲載誌：弘前医学, 67(1), 13-27, 2016
97.

学位論文
学位
97. Beneficial effect of 4-Methylumbelliferone against bile duct ligation-induced hepatic fibrosis in rats
Sawada, Naoya
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5879
概要: 掲載誌弘前医学, 66(2-4), p.143-151, 2016
98.

学位論文
学位
98. Image Processing Method for Visualizing White Zone in Magnifying Endoscopy with Narrow-band Imaging of Gastric Mucosa
Yoshida, Kenta
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5881
概要: 掲載誌弘前医学, 66(2-4), p.152-161, 2016
99.

学位論文
学位
99. NF-κB-dependent increase in tissue factor expression is responsible for hypoxic podocyte injury
Narita, Ikuyo
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5882
概要: 掲載誌Clinical and Experimental Nephrology, 20(5), p.679-688, 2016
100.

学位論文
学位
100. Hyperinsulinemia Lead the Elevation of Plasma Aldosterone Concentration Independently with Obesity, Dyslipidemia, and Insulin Resistance in Patients with Type 2 Diabetes Mellitus
Kimura, Yuki
出版情報: 2016-03-23. 
URL: http://hdl.handle.net/10129/5883
概要: 掲載誌弘前医学, 65(1), 2014, p.35-42