＜Special Seminar＞Molecular mechanism of sleep-wake regulation

フォーマット:

論文

責任表示:

Urade, Yoshihiro

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2010-07-08

著者名:

Urade, Yoshihiro  

掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

61

通号:

Supplement

開始ページ:

S164

終了ページ:

S173

バージョン:

publisher

概要:

Prostaglandin（ PG） D2 is the most potent endogenous sleep-promoting substance thus far reported and its sleep-inducing mechanism is the best characterized at the molecular level. PGD2 is produced by lipocalin-type PGD synthase （L-PGDS） loca … lized in the leptomeninges, choroid plexus, and oligodendrocytes in the brain and is secreted into the cerebrospinal fluid as a sleep hormone. PGD2 stimulates DP1 receptors localized in the arachnoid membrane at the basal forebrain to release adenosine as a paracrine sleep-promoting molecule, which activates adenosine A2A receptor-expressing neurons located in the basal forebrain. These cells subsequently excite the sleep-active neurons in the ventrolateral preoptic area and concomitantly suppress the tuberomammillary nucleus, a histaminergic arousal center, through GABAergic and galaninergic inhibitory projection, to induce sleep. The administration of a PGD synthase inhibitor （SeCl4）, DP1 antagonist （ONO-4127Na） or adenosine A2 receptor antagonist （caffeine） induces insomnia, indicating that the PGD2-adenosine system is crucial for the maintenance of physiological sleep. 続きを見る

URL:

http://hdl.handle.net/10129/3683