＜Symposium I＞Prandial increases of leptin and orexin in the brain modulate spatial learning and memory

フォーマット:

論文

責任表示:

Oomura, Yutaka ; Aou, Shuji ; Fukunaga, Kouji ; Moriguchi, Sigeki ; Sasaki, Kazuo

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2010-07-08

著者名:

• Oomura, Yutaka
• Aou, Shuji
• Fukunaga, Kouji
• Moriguchi, Sigeki
• Sasaki, Kazuo

掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

61

通号:

Supplement

開始ページ:

S1

終了ページ:

S10

バージョン:

publisher

概要:

Leptin is well known to be involved in the inhibition of feeding, thermogenesis, reproduction and neuroendocrine functions through its actions on the rodent hypothalamic receptors. Leptin facilitated the presynaptic transmitter release and … postsynaptic sensitivity to the transmitters in the hippocampal CA1 neurons. Thus longterm potentiation （LTP） and the phosphorylation of Ca2+/calmodulin protein kinase II （CaMK II） were facilitated in the CA1 neurons. Therefore behavioral performance related to spatial learning and memory was improved by leptin in vivo applications. Orexin-A produced by glucose-sensitive neurons in the lateral hypothalamic area （LHA）and released during food intake facilitates feeding. Orexin-A suppressed LTP and CaMK II phosphorylation without affecting the presynaptic transmitter release. Therefore behavioral performance on learning and memory was impaired. The present studies suggest that leptin and orexin signalings in the brain may have important implications for cognitive function. 続きを見る

URL:

http://hdl.handle.net/10129/3664