Vaccination with a nontoxic mutant of staphylococcal enterotoxin C elicits Th2 immune response for protection against Staphylococcus aureus infection

フォーマット:

論文

責任表示:

Hu, Dong-Liang ; Omoe, Katsuhiko ; Narita, Koji ; Shinagawa, Kunihiro ; Nakane, Akio

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2007-11-29

著者名:

• Hu, Dong-Liang
• Omoe, Katsuhiko
• Narita, Koji
• Shinagawa, Kunihiro
• Nakane, Akio

掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

59

通号:

Supplement

開始ページ:

S210

終了ページ:

S218

バージョン:

publisher

概要:

To develop a Staphylococcus aureus vaccine, we constructed and expressed a non-toxic mutant staphylococcalenterotoxin C（ mSEC） and investigated whether immunization with mSEC can protect against S. aureus infection. Micewere immunized with … mSEC and challenged with viable S. aureus. Bacteria counts in the organs in mSEC-immunizedmice were significantly lower and the survival rate was higher than those of the control group. mSEC vaccinationinduced the production of T-helper 2 type antibodies. The production of interleukin-10（ IL-10） and IL-4 in vaccinatedmice was signifi cantly higher compared with the control group, whereas the production of gamma interferon （IFN-γ.）was signifi cantly decreased in the vaccinated mice. Furthermore, IFN-γ.and tumor necrosis factor-α・ production in vitrowas signifi cantly inhibited by the sera from mSEC-vaccinated mice but not by those from control mice. These resultssuggest that vaccination with mSEC provides protection against S. aureus infection. SEC neutralizing antibodies and theIL-10 and IL-4 induction might play important role for the protection. 続きを見る

URL:

http://hdl.handle.net/10129/2238