New functions of classical hormone α-melanophore-stimulating hormone
- フォーマット:
- 論文
- 責任表示:
- Tonosaki, Yoshikazu ; Sugiura, Yasuo ; Roubos, Eric W.
- 言語:
- 英語
- 出版情報:
- 弘前大学大学院医学研究科・弘前医学会, 2007-11-29
- 著者名:
- 掲載情報:
- 弘前医学
- ISSN:
- 0439-1721
- 巻:
- 59
- 通号:
- Supplement
- 開始ページ:
- S202
- 終了ページ:
- S209
- バージョン:
- publisher
- 概要:
- It is well-known that α-melanophore-stimulating hormone (α-MSH) release from the amphibian parsintermedia( PI) depends on the light condition of the animal’s background. In the present study, we present two newfunctions of … α-MSH in amphibians and mammals. In Xenopus laevis, we show that temperatures below 8 ℃ stimulateα-MSH secretion of the PI and skin darkening, with a maximum at 5 ℃, under regulation of the hypothalamus rule,independently from the illumination state of the background. The cold-induced α-MSH release of the PI was inhibited byneuropeptide-Y-producing suprachiasmatic-melanotrope-inhibiting neurons in the ventrolateral area of the suprachiasmaticnucleus but increasely in thyrotropin-releasing-hormene-containing neurons of the magnocellular nucleus. It is knownthat intracerebroventricular( ICV) administration of a low dose of interleukin-1β( IL-1β) induces hyperalgesia in ratand that this eff ect can be inhibited by α-MSH. To identify the part of the brain that is aff ected by hyperalgesiainducingIL-1β and the site of α-MSH concerned, we have examined Fos expression in the brain in response to ICVmicroinjection of α-MSH and/or IL-1β. Following injection of 10 pg IL-1β, hyperalgesia was induced and Fos becameexpressed in the paraventricular nucleus( PVN) of the hypothalamus and in the arcuate nucleus( ARC), which containsα-MSH-producing neurons. ICV co-injection of IL-1β ・ with 30 ng α-MSH fully inhibited both hyperalgesia and Fosexpression in the PVN and the ARC. We conclude that PVN neurons are activated by hyperalgesic IL-1β and proposethat this eff ect is abolished by α-MSH released from the ARC but not from the pituitary gland. 続きを見る
- URL:
- http://hdl.handle.net/10129/2237
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