V1a vasopressin receptor gene single nucleotide polymorphism and essential hypertension, type 2 diabetes mellitus and platelet aggregation

フォーマット:

論文

責任表示:

Hasan, Kazi N. ; Shoji, Masaru ; Sugimoto, Kazuhiro ; Tsutaya, Shoji ; Matsuda, Eriko ; Kudo, Ryoko ; Saito, Junko ; Nakaji, Shigeyuki ; Suda, Toshihiro ; Yasujima, Minoru

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2007-11-29

著者名:

Hasan, Kazi N.

Shoji, Masaru

Sugimoto, Kazuhiro

Tsutaya, Shoji

Matsuda, Eriko

Kudo, Ryoko

Saito, Junko

Nakaji, Shigeyuki

Suda, Toshihiro

Yasujima, Minoru

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掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

59

通号:

Supplement

開始ページ:

S119

終了ページ:

S127

バージョン:

publisher

概要:

Candidate gene SNP study is a promising genetic approaches to complex common disorders. Argininevasopressin （AVP）, a peptide hormone released from the posterior pituitary, has been suggested to play importantroles in the regulation of blood … pressure, glycogenolysis and platelet aggregation through G protein coupled V1areceptor （V1aR）. Thus, polymorphisms in the V1aR gene have been prospective as possible genetic markers foressential hypertension, type 2 diabetes mellitus and divergent platelet aggregation response to AVP. We identifi ed 4novel single nucleotide polymorphisms（ SNPs） in the promoter region of the V1aR gene and named according to theupstream locations such as, -6951G/A, -4112A/T, -3860T/C, and -242C/T. We investigated the association of 4 SNPs ofthe V1aR gene in 365 hypertensive and 255 healthy subjects, 186 T2DM patients and 188 non-diabetic control subjects（CS）, and 33 young healthy volunteers living in the Aomori prefecture. Signifi cant association was identifi ed betweenSNP at -6951 and hypertension in nonobese individuals, at -6951 and type 2 diabetes mellitus. Positive association wasalso identifi ed between nonobese hypertension and haplotype H3. Signifi cant association was demonstrated betweenSNP at -6951 and glycemic status in young healthy subjects. However, there was no signifi cant association in the AVPinducedplatelet aggregation with V1aR gene variants. The study suggests V1aR gene variants as increased riskfor hypertension in nonobese and type 2 diabetes mellitus in the Aomori population; however, might not be useful asgenetic markers for platelet aggregation heterogeneity. 続きを見る

URL:

http://hdl.handle.net/10129/2225