Rejuvenation of T cell memory

フォーマット:

論文

責任表示:

Kurachi, Makoto ; Kakimi, Kazuhiro ; Ueha, Satoshi ; Matsushima, Kouji

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2007-11-29

著者名:

• Kurachi, Makoto
• Kakimi, Kazuhiro
• Ueha, Satoshi
• Matsushima, Kouji

掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

59

通号:

Supplement

開始ページ:

S26

終了ページ:

S34

バージョン:

publisher

概要:

Memory CD8+ T cells generated during an immune response are long-lived and self-renewing, off eringenhanced host protection against re-infection. However, how an antigen-specific population of memory T cells ismaintained throughout repetiti … ve infections over potentially a lifetime is not known. Here we review the generationand maintenance of antigen-specifi c CD8+ T cells and introduce our recent data showing dynamic turnover of anantigen-specific memory T cell population during repeated antigen challenge in vivo. We demonstrated that aprimary response potentially occurs upon every recall response and fi nd that the skewed T-cell receptor （TCR）repertoire of pre-existing memory T cells is partly corrected by diversity in a newly formed （primary） population.Importantly, memory T cells generated in a more recent antigen encounter expand more vigorously in a subsequentrecall response. A primary response during re-challenge therefore restores both the TCR diversity and proliferativepotential of the memory T cell population. These findings indicate that memory T cell populations evolve overmultiple challenges, favoring memory T cells generated in more recent encounters, and suggest that these primarypopulations have essential roles in the perpetuation of antigen-specifi c T cell populations. 続きを見る

URL:

http://hdl.handle.net/10129/2213