New approaches for prevention and treatment of infl uenza virus infection by an enhancement of mucosal immunization and suppression of protease expression

フォーマット:

論文

責任表示:

Kido, Hiroshi ; Mizuno, Dai ; Le, Quang Trong ; Chida, Junji ; Yamada, Hiroshi ; Okumura, Yuushi ; Yano, Mihiro

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2007-11-29

著者名:

Kido, Hiroshi

Mizuno, Dai

Le, Quang Trong

Chida, Junji

Yamada, Hiroshi

Okumura, Yuushi

Yano, Mihiro

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掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

59

通号:

Supplement

開始ページ:

S19

終了ページ:

S25

バージョン:

publisher

概要:

Human infl uenza virus causes an annual epidemic infection. After infl uenza virus infection in the airway,infection sometimes spreads with severe neurologic complication and multiple organ failure, resulting in highmortality. In the proces … s of viral spread from the lungs to other organs, signifi cant up-regulated trpsin was observedin various organs. Up-regulated trypsin eff ectively converted precursor of the viral envelope hemagglutinin（ HA） intoHA1 and HA2 subunits. The proteolytic activation of HA is a prerequisite for virus multiplication. Administration ofthe inhibitors of trypsin as new approaches for the treatment of infl uenza virus infection eff ectively suppressed viralmultiplication. Almost vaccines for infl uenza virus infection are administered i.m. or s.c., which induce IgG-mediatedprotection in the systemic immune compartment, but this immunization off ers insuffi cient protection on the mucosalsurface at the initial site of viral multiplication. To improve protective mucosal immunity, intranasal vaccinationhas been studied. The powerful mucosal adjuvants reported are toxin based, such as cholera toxin and Escherichiacoli heat-labile toxin, but these enterotoxins cause severe side eff ects. We recently found natural mucosal adjuvant,pulmonary surfactant, in the lungs. Intranasal administration of infl uenza vaccine combined with Surfacten, a modifi edpulmonary surfactant free of antigenic c-type lectins, induced high protective mucosal immunity in the airway andsystemic immune responses in the blood, the effi cacy of both protective immunities by Surfacten being equivalent tothose by cholera toxin. In this symposium, we reported the eff ects of Surfacten on mucosal and systemic immunities. 続きを見る

URL:

http://hdl.handle.net/10129/2212