Human parvovirus B19 and rheumatoid arthritis

フォーマット:

論文

責任表示:

Sasaki, Takeshi

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2007-11-29

著者名:

Sasaki, Takeshi  

掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

59

通号:

Supplement

開始ページ:

S12

終了ページ:

S18

バージョン:

publisher

概要:

Human parvovirus B19 （B19） is single stranded DNA virus, that causes erythema infectinosum in infantand/or acute onset polyarthritis in adult. We present the evidence showing the role of B19 on the etiopathogy ofrheumatoid arthritis（ RA）.（ … 1） B19 DNA could be frequently amplifi ed in the samples from rheumatoid joints. Thedetection B19 RNA and B19 protein VP1 was specific for RA, and positive at T cells, B cells, macrophages andfollicular dendritic cells in rheumatoid synovium. （ 2） B19 infection or transduction of B19 NS1gene caused TNFα,IL-6 and IL-8 production through activating AP1 and AP2 in macrophages or macrophage celll line U937. We alsofound Ku80 as a novel receptor for B19 on T cells, macrophages or erythroblasts. B19 used clathrin on the surface attheir cell entry and caused enhanced actin polymerization, resulting in the migration of T cells. （ 3） B19-transgenicmice became susceptible to type II collagen-induced polyarthritis that is a model of RA. We also experienced 12cases who developed RA after acute B19 infection. （ 4） Half of RA cases had a defective neutralizing ability to B19. 続きを見る

URL:

http://hdl.handle.net/10129/2211