Experimental Studies on Morphological Changes of the Epididymis and Testis in Neonatally Estrogenized Mice Revisited

フォーマット:

論文

責任表示:

Kachi, Takashi ; Kachi, Hitomi

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2007-11-29

著者名:

• Kachi, Takashi
• Kachi, Hitomi

掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

59

通号:

Suppl.

開始ページ:

S278

終了ページ:

S287

バージョン:

publisher

概要:

Our primary concern in this review is to give possible explanations and pose new questions on the phenomenaconcerning effects of neonatal estrogen exposure on the development and functions of reproductive organs and immunemechanisms particularly in male animals, in the light of new findings and cencepts. At first, our own experimental resultson the pathological changes in the epididymis and testis in neonatally estrogenized mice have been presented. The resultsof … our first experiment showed that neonatal single injection of 10 flg of estradiol benzoate induced marked inflammatorychanges in the epididymis and testis, in which the initial pathological change occurred concomitantly with the appearanceof sperms in the epididymal duct. The second experiment showed that such epididymo-testicular changes did not occurwhen the testis was removed or neonatal estrogen was followed by testosterone. From these results, a possibility wassuggested that a hormone-related autoimmune mechanism might participate in such changes. Relating to these, variousreports concerning effects of neonatal estrogen treatment, either alone or with concommitent treatment with androgen.on the development and functions of reproductive organs and immune mechanisms in the adolescent or adult have beenreviewed. In addition, advances in the related areas, such as estrogen-related mechanisms in the development andfunctions of reproductive organs and immune mechanisms including autoimmune disease mechanisms. gender differencesand the role of CD25+ CD4+ T lymphocytes have also been reviewed briefly. 続きを見る

URL:

http://hdl.handle.net/10129/1890