Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model

Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model

フォーマット:

論文

責任表示:

Horiuchi, Daisuke ; Osanai, Tomohiro ; Echizen, Takashi ; Ashitate, Toshihiro ; Kato, Chisato ; Yokoyama, Hiroaki ; Hanada, Kenji ; Shibutani, Shuji ; Itoh, Taihei ; Okumura, Ken

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2009-03-31

著者名:

掲載情報:

弘前医学

ISSN:

0439-1721

巻:

60

通号:

1/2/3/4

開始ページ:

45

終了ページ:

53

バージョン:

publisher

概要:

Structural remodeling occurs in diverse heart diseases and affects their clinical courses. We reportedthat amiodarone suppresses both electrical and structural remodeling in a canine persistent atrial fi brillation model.As a mechanism for … amiodarone’s effect on structural remodeling, we suggested its inhibitory effect on matrixmetalloproteinase（ MMP） activity. To elucidate it, we investigated the eff ect of amiodarone on MMP activity in a ratmyocardial infarction model created by left coronary artery（ LCA） ligation. Adult Sprague-Dawley rats were dividedinto sham-operated （Sham）, sham-operated with amiodarone （Sham+AMD）, LCA-ligated without amiodarone （MI）and LCA-ligated with amiodarone rats （MI+AMD）. Amiodarone （20 mg/kg/day） was administered for 2 weeksbefore and for 4 weeks after operation. The hearts were excised at 4 weeks after operation. MMP-2 activity wasmeasured by gelatin zymography. At 4 weeks after surgery, left ventricular fractional shortening was decreased inMI but not in MI+AMD rats. There was no diff erence in the infarct size between MI and MI+AMD rats （P=NS）.As compared with Sham, MMP-2 activity was increased in MI （P<0.01）, but not in MI+AMD （P=NS versus Sham;P<0.05 versus MI）. MMP-2 activity was not increased in Sham+AMD（ P=NS）. Thus, amiodarone exerts an inhibitoryeff ect on MMP activity. This may be related to the improvement left ventricular function in MI rats. 続きを見る

URL:

http://hdl.handle.net/10129/1797

タイトルが類似している資料

詳細

その他の標題:	アミオダロンのマトリックスメタロプロテイナーゼ-2 活性に対する作用：ラット心筋梗塞モデルでの検討アミオダロンノマトリックスメタロプロテイナーゼ -2 カッセイニタイスルサヨウ : ラットシンキンコウソクモデルデノケントウ
主題:	amiodarone; matrix metalloproteinases; myocardial infarction; structural remodeling; アミオダロン; マトリックスメタロプロテイナーゼ; 心筋梗塞; 構造的モデリング
受理日:	2009-03-31

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