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論文
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Hasegawa, Kazushi ; Oikawa, Koichi ; Yoshida, Ikko ; Ishizaka, Hiroshi ; Osanai, Tomohiro ; Motomura, Shigeru ; Okumura, Ken
概要:
To examine the effect of chronic hypertension on endothelium-derived hyperpolarizing factor（ EDHF）responses, the hearts
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of Wistar-Kyoto rats（ WKY） and spontaneously hypertensive rats（ SHR） were isolated andperfused using Langendorff system with constant perfusion pressure. Bradykinin increased coronary fl ow（ CF） dosedependentlyand this was not aff ected by NG-nitro-L-arginine methyl ester or indomethacin, indicating that bradykinin’seff ect on CF was not mediated by nitric oxide or prostacyclin but by EDHF. Bradykinin-induced CF increase was smallerin SHR than in WKY. Tetrabutylammonium（ a non-specific KCa channel blocker） abolished bradykinin-induced CFincrease in both rats. 1-Ethyl-2-benzimedazolinone（ 1-EBIO, an agonist of intermediate conductance KCa channel）-inducedincrease in CF was smaller in SHR than in WKY. 1,3-Dihydro-1-[2-hydroxy-5（- trifl uoromethyl） phenyl]-5（- trifl uoromethyl）-2H-benzimidazol-2-one（ NS1619, an agonist of large conductance KCa channel）-induced increase in CF did not differbetween SHR and WKY. In early stage of hypertension, there was no signifi cant diff erence between SHR and WKY inbradykinin- and 1-EBIO-induced increases in CF. In conclusion, EDHF response in coronary microcirculation is impairedin SHR due to dysfunction of intermediate-conductance calcium-activated potassium channels.
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| 2.
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論文
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Kitajima, Yu ; Yamabe, Hideaki ; Yasujima, Minoru
概要:
Background: Chronic kidney disease (CKD) is a major worldwide public health problem. Although CKD is widely known to cause stroke, evaluation of renal function in stroke patients is diffi cult. Purpose: We aimed to determine the
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prevalence of CKD in stroke patients and demonstrate the validity of estimated glomerular fi ltration rate (eGFR) measurement to assess renal function in patients after stroke. Subjects and Methods: We examined the prevalence of CKD in 545 stroke patients and assessed correlations between eGFR and biochemical data, prevalence of hypertension, diabetes mellitus, hypercholesterolemia, and atrial fi brillation (AF). Results: Of the 545 patients, 178 (32.8%) had CKD with a low eGFR (<60 mL/min/1.73 m2). eGFR was negatively correlated with age, serum uric acid and creatinine concentrations, and positively correlated with hemoglobin levels. Moreover, eGFR was correlated with the prevalence of hypertension and AF, but not diabetes mellitus or hypercholesterolemia. Conclusions: High prevalence of CKD was observed in stroke patients. Measurement of eGFR can be useful in evaluating renal function in stroke patients.
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