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Tanikawa, Ryoko ; Takahashi, Ippei ; Okubo, Noriyuki ; Ono, Masami ; Okumura, Toshiki ; Ishibashi, Goshi ; Takeishi, Yosuke ; Nakayama, Maki ; Yano, Tomohiko ; Kumasaka, Yoshihiro ; Nakaji, Shigeyuki
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| 2.
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Sato, Satoshi ; Komame, Hitomi ; Akimoto, Naoki ; Sawada, Kaori ; Tanaka, Rina ; Munakata, Osamu ; Iizuka, Hiroshi ; Shibata, Nobuyuki ; Nakaji, Shigeyuki
概要:
There are certain sex differences in the prevalence and severity of immunity-related diseases. Previousstudies have show
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n the influence of sex steroid hormones, such as estrogen and testosterone, on the immune system.The aim of this study was to investigate the association of sex steroid hormones with neutrophil function amongnormal healthy subjects in the general population. Subjects included 540 residents（ 358 males and 182 females）, whoparticipated in the Iwaki Health Promotion Project in 2014. We examined the association of estradiol and testosteronewith neutrophil ROS production and phagocytic activity. As a result, estradiol and testosterone negatively correlatedwith basal ROS production in males and luteal phase females （>15th day of menstrual cycle）, although such trendwas not observed in follicular phase females（ <14th day of menstrual cycle） and postmenopausal females. In contrast,the association of testosterone with stimulated ROS production and phagocytic activity was observed only in males.In conclusion, both estradiol and testosterone were found to have an influence on neutrophil function. Furthermore,the association of sex steroid hormones with neutrophil function was found to vary according to the phase of the menstrual cycle in addition to the sex difference.
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| 3.
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論文
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Tanaka, Rina ; Matsuzaka, Masashi ; Takahashi, Ippei ; Sawada, Kaori ; Nakaji, Shigeyuki ; Sasaki, Yoshihiro
概要:
It has been reported that an association between gut microbiota and obesity, and changes in the composition of gut micro
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biota have been reported with aging. The aim of this study is clarify the relationship between obesity and gut microbiota as a function of age. Furthermore, the impact of lifestyle factors（ alcoholic drink and smoking） on gut microbiota were discussed. Fecal samples from 1082 healthy Japanese adults aged 19–90 years who participated in the Iwaki Health Promotion Project in 2014 were analyzed by using 16S rDNA gene-targeted sequencing. The participants were stratified into six age groups: ≤39, 40–49, 50–59, 60–69, 70–79 and ≥80. The participants with a body mass index （BMI） of <25 kg/m2 were classified as non-obese, and those with a BMI of ≥25 kg/m2 were classified as obese. Changes in the composition of gut microbiota with age were different between the obese and non-obese groups.Bacterial diversity decreased with age at the phylum level, however, this diversity was not observed at the class level. The abundances of certain gut microbiota, such as Bacteroidetes and Firmicutes, were different between the obese and non-obese groups. There were no significant differences in alcoholic and smoking habits. Bacterial diversity was different with age between the obese and non-obese group. The composition of Bacteroidetes and Firmicutes changed with increasing age in the obese group.
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論文
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Iida, Keiichiro ; Nakaji, Shigeyuki ; Mikami, Makoto ; Yokoi, Katsunori ; Saito, Yuriko ; Wada, Naoko ; kasai, Sayaka ; Fukushima, Manabu ; Higuchi, Ayako ; Urushidate, Satoshi
概要:
Background: Ptosis is caused mainly by age-related degeneration of the aponeurosis caused by lifestylerelateddiseases. S
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ome patients with ptosis complain of stiff shoulders and headaches. There have been few actualepidemiological investigations of aponeurotic ptosis and these symptoms. We aimed to find their prevalence andassociated characteristics of ptosis in Japanese general population.Methods: The target population consisted of 1004 volunteers who took part in the 2016 Iwaki Health PromotionProject. We administered a questionnaire, took blood samples, took physical measurements, and measured marginalreflex distance（ MRD-1） in each participant. The relationship between survey items（ age, gender, difficulty in raisingeyelids, headache, stiff shoulders, hypertension, diabetes, dyslipidemia, and body mass index［ BMI］） and eyelid droopwas examined statistically.Results: The prevalence of ptosis in this study was 15.4%. Ptosis prevalence correlated with elderly people 65years or older （odds ratio. 3.07, 95% CI: 2.02–4.66）, male sex （odds ratio. 0.29, 95% CI: 0.20–0.43）, hypertension （oddsratio. 1.68, 95% CI: 1.11–2.54） and dyslipidemia（ odds ratio. 1.51, 95% CI: 1.02–2.23）.Conclusions: The present results suggested that hypertension, dyslipidemia and male sex were thought to be therisk factors of aponeurotic ptosis in Japanese general population.
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