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論文
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Yamai, Kiyonori ; Umeda, Takashi ; Matsuzaka, Masashi ; Danjo, Kazuma ; Takahashi, Ippei ; Tsuya, Ryosuke ; Hasebe, Tatsuya ; Nakaji, Shigeyuki
概要:
We examined the effects of vitamin C supplementation on neutrophil function during exercise loading.Neutrophil functions
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, namely the reactive oxygen species （ROS） production capability, neutrophil phagocytic activity（PA） and serum opsonic activity （SOA） were measured before and after a 2-hour unified loading exercise （ULE）both before and after a 7-day intensified training camp for 22 male judoists. The parameters were assessed neutrophilcount, myogenic enzymes, vitamin C in serum, SOA, PA, ROS production capability, body composition, and so on.Subjects were randomly assigned to two groups; the VC group （daily diet supplementation of 1,500 mg vitamin C）and the Control group （no vitamin C supplementation）. The post-camp pre-ULE vitamin C level was higher in theVC group than in the Control group, though no such difference was seen at pre-camp. As for neutrophil function,although the typical changes seen following a single bout of normal exercise, namely an increase in SOA and ROS,and a decrease in PA, were recorded following the pre- and post-camp ULEs in both groups, significant differencein change rates were not seen between both groups. In conclusion, vitamin C supplementation had no significantinfluence on changes in neutrophil function.
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| 2.
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Ito, Haruyuki ; Takahashi, Ippei ; Matsuzaka, Masashi ; Lee, Sangun ; Itai, Kazuyoshi ; Fukui, Shinji ; Hamada, Naoko ; Saito, Yuriko ; Umeda, Takashi ; Nakaji, Shigeyuki
概要:
Objective: We investigated the relationship between trace element concentrations and neutrophil basalreactive oxygen spe
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cies（ ROS） production capability among the Japanese general population. Subjects and methods: Subjects of the current study were 606 participants（ 225 males and 381 females） who had participated in the Iwaki Health Promotion Project 2005. Body mass index, biochemical blood examination, neutrophilbasal ROS production and serum concentrations of trace element （Copper（Cu）, Zinc（Zn）, Iron（Fe）, Selenium（Se）） were measured. Each trace element was divided into 4 quartiles according to the concentration, and theneutrophil basal ROS production of each group was compared and analyzed. Moreover, the relationship between the concentration and neutrophil basal ROS production capability was assessed using a multiple linear regression analysis. Results: For both males and females, a tendency to low neutrophil ROS production associated with higher Se serum concentration was observed. On the other hand, no significant correlation was observed between the Cu, Zn and Fe concentrations and neutrophil basal ROS production capability. Conclusion: In conclusion, serum Se relieves oxidative stress through inhibiting neutrophil ROS production within a physiological range. On the other hand, our results suggested that neutrophil ROS production was unaffected by Cu, Zn and Fe concentrations within the normal physiological range.
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| 3.
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Takeishi, Yosuke ; Hasebe, Tatsuya ; Umeda, Takashi ; Takahashi, Ippei ; Sawada, Kaori ; Okubo, Noriyuki ; Totsuka, Manabu ; Yoneda, Katsuro ; Suzukawa, Kazuhiro ; Nakaji, Shigeyuki
概要:
An intensive training performed by athletes causes accumulation of physical fatigues, which leads to immunity depression
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and overtraining syndrome. Especially in endurance sports, physical fatigue tends to accumulate as it takes time to recover from physical conditions after the race or intensive training. In this study, we have investigated the conditions of marathon runners after one week of Ekiden （relay road race） according to the levels of muscle enzymes and serum opsonic activity （SOA）. Subjects were 28 top male runners in Japanese University Ekiden. Out of all 28 subjects, 11 of them who had a race before a week of investigation were considered as the race group, and the rest were considered as the control group. Although no significant difference were found in running distance and duration of training among the two groups, muscular enzyme levels were significantly high （p<0.05）,and SOA levels of LgCL, PH and AUC tended to be higher in the race group than the control group. This showed the higher damage of the muscle, and a possibility that it may have reflected the increase in ROS production in the race group compared to the control group. In conclusion, there was a possibility that the endurance of athletes were not fully recovered from the muscle fatigue causing increase of ROS production even after a week of the race. Therefore,long-distance runners were suggested to carry out a reduced amount of less-intense, less-frequent training with sufficient rests at least for a week after a race competition.
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| 4.
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Tanikawa, Ryoko ; Takahashi, Ippei ; Okubo, Noriyuki ; Ono, Masami ; Okumura, Toshiki ; Ishibashi, Goshi ; Takeishi, Yosuke ; Nakayama, Maki ; Yano, Tomohiko ; Kumasaka, Yoshihiro ; Nakaji, Shigeyuki
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| 5.
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福井, 真司 ; 梅田, 孝 ; 沢田, かほり ; 高橋, 一平 ; 浜野, 学 ; 三宅, 良輔 ; 小山田, 和行 ; 椿原, 徹也 ; 田中, 充洋 ; 須田, 芳正 ; 中路, 重之
概要:
サッカーの試合における脱水状況が免疫機能に及ぼす影響について調査・検討した．対象は大学女子サッカー選手15名である．調査は90分間の試合前後に実施した．測定項目は身体組成，筋逸脱酵素，白血球数，好中球機能（活性酸素種産生能，貪食能）であった
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．全対象で試合後の有意な体重減少がみられ，体水分の減少が認められた．これより，試合前後の総蛋白濃度変化により2 群に分類し（軽度脱水群と高度脱水群），各測定値を比較した．筋逸脱酵素値は両群ともに試合後有意に上昇していたが，変化率は両群で差がなかった．白血球数は試合後有意に上昇し，その変化率は高度脱水群の方が大きかった．好中球機能は，軽度脱水群では活性酸素種産生能が上昇し，高度脱水群では活性酸素種産生能および貪食能が低下していた．同じ強度の運動をしていても，脱水による血液中の水分喪失が大きい者ほど，好中球機能の低下が引き起こされる可能性が示唆された．
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| 6.
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論文
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Sato, Satoshi ; Komame, Hitomi ; Akimoto, Naoki ; Sawada, Kaori ; Tanaka, Rina ; Munakata, Osamu ; Iizuka, Hiroshi ; Shibata, Nobuyuki ; Nakaji, Shigeyuki
概要:
There are certain sex differences in the prevalence and severity of immunity-related diseases. Previousstudies have show
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n the influence of sex steroid hormones, such as estrogen and testosterone, on the immune system.The aim of this study was to investigate the association of sex steroid hormones with neutrophil function amongnormal healthy subjects in the general population. Subjects included 540 residents（ 358 males and 182 females）, whoparticipated in the Iwaki Health Promotion Project in 2014. We examined the association of estradiol and testosteronewith neutrophil ROS production and phagocytic activity. As a result, estradiol and testosterone negatively correlatedwith basal ROS production in males and luteal phase females （>15th day of menstrual cycle）, although such trendwas not observed in follicular phase females（ <14th day of menstrual cycle） and postmenopausal females. In contrast,the association of testosterone with stimulated ROS production and phagocytic activity was observed only in males.In conclusion, both estradiol and testosterone were found to have an influence on neutrophil function. Furthermore,the association of sex steroid hormones with neutrophil function was found to vary according to the phase of the menstrual cycle in addition to the sex difference.
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