1.
学位論文 |
Kubo, Kohmei
概要:
授与大学:弘前大学; 学位種類:医学博士; 授与年月日:平成3年3月20日; 学位記番号:医博甲846第号
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2.
学位論文 |
Kawasaki, Hitoshi
概要:
授与大学:弘前大学; 学位種類:医学博士; 授与年月日:平成3年3月20日; 学位記番号:医博甲第847号
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3.
学位論文 |
Takeda, Yusuke
概要:
授与大学:弘前大学; 学位種類:博士(医学); 授与年月日:平成5年3月24日; 学位記番号:医博甲第960号
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4.
学位論文 |
土岐, 力
概要:
授与大学:弘前大学; 学位種類:博士(医学); 授与年月日:平成9年9月16日; 学位記番号:医博乙第782号
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5.
学位論文 |
浅野, 研一郎
概要:
授与大学:弘前大学; 学位種類:博士(医学); 授与年月日:平成10年3月25日; 学位記番号:医博甲第1225号
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6.
学位論文 |
平元, 周
概要:
授与大学:弘前大学; 学位種類:博士(医学); 授与年月:平成9年3月26日; 学位記番号:医博乙第760号
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7.
学位論文 |
Kon, Tomoya
概要:
http://onlinelibrary.wiley.com/doi/10.1111/neup.12056/citedby
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8.
学位論文 |
Ueno, Tatsuya
概要:
http://www.sciencedirect.com/science/article/pii/S0969996113003586
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9.
学位論文 |
Nishijima, Haruo
概要:
http://onlinelibrary.wiley.com/doi/10.1002/mds.25826/abstract
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10.
学位論文 |
Sato, Tsugumi
概要:
本文はJ-Stageより転載。
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11.
学位論文 |
Yakoshi, Yuta
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12.
学位論文 |
Imanishi, Kengo
概要:
http://www.spandidos-publications.com/mmr/9/6/2159
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13.
学位論文 |
Okamoto, Teppei
概要:
http://www.spandidos-publications.com/mmr/7/2/359
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14.
学位論文 |
14. Extravasation during bladder cancer metastasis requires cortactin‑mediated invadopodia formation
Tokui, Noriko
概要:
http://www.spandidos-publications.com/mmr/9/4/1142
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15.
学位論文 |
Hirokawa, Hachidai
概要:
http://www.ovarianresearch.com/content/7/1/4
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16.
学位論文 |
Itoh, Ryohei
概要:
https://www.jstage.jst.go.jp/article/biomedres/35/1/35_69/_article
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17.
学位論文 |
Kon, Takao
概要:
https://www.jstage.jst.go.jp/article/biomedres/35/1/35_9/_article
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18.
学位論文 |
Saito, Yuki
概要:
http://www.annals-general-psychiatry.com/content/12/1/20
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19.
学位論文 |
Narita, Norihiko
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20.
学位論文 |
Ishida, Yuji
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21.
学位論文 |
Endo, Tomohide
概要:
http://link.springer.com/article/10.1007/s00380-013-0435-x
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22.
学位論文 |
Suzuki, Akiko
概要:
http://www.nature.com/hr/journal/vaop/ncurrent/full/hr201465a.html
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23.
学位論文 |
Tateyama, Shunta
概要:
http://www.sciencedirect.com/science/article/pii/S1880427614000076
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24.
学位論文 |
Nomura, Anan
概要:
http://www.sciencedirect.com/science/article/pii/S0006291X13016574
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25.
学位論文 |
Sasaki, Shizuka
概要:
http://link.springer.com/article/10.1007/s00776-013-0420-3
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26.
学位論文 |
Harada, Yoshifumi
概要:
http://www.sciencedirect.com/science/article/pii/S0006291X13021517
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27.
学位論文 |
有賀, 玲子
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28.
学位論文 |
谷川, 涼子
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29.
学位論文 |
小西, 裕之
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30.
学位論文 |
Yoneda, Katsuro
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31.
学位論文 |
Masahara, Hidetaka
概要:
http://www.karger.com/Article/FullText/355093 © 2014 S. Karger AG, Basel
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32.
学位論文 |
Tanaka, Hisashi
概要:
http://www.sciencedirect.com/science/article/pii/S0169500213001116
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33.
学位論文 |
Tanaka, Yoshihito
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34.
学位論文 |
Yamagata, Satoshi
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35.
学位論文 |
Watanuki, Yutaka
概要:
http://www.sciencedirect.com/science/article/pii/S0303720713000452
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36.
学位論文 |
Funamizu, Ayano
概要:
http://onlinelibrary.wiley.com/doi/10.1111/aji.12206/abstract
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37.
学位論文 |
Kobayashi, Tamotsu
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38.
学位論文 |
Sawada, Masahiro
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39.
学位論文 |
Oyamada, Kazuyuki
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40.
学位論文 |
Sakamoto, Yuki
概要:
https://www.jstage.jst.go.jp/article/internalmedicine/53/11/53_53.2159/_article
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41.
学位論文 |
Tomita, Tetsu
概要:
http://onlinelibrary.wiley.com/doi/10.1111/pcn.12102/abstract
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42.
学位論文 |
Meng, Pengfei
概要:
http://www.sciencedirect.com/science/article/pii/S0168010212002349
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43.
学位論文 |
Tobishima, Hana ; Hatayama, Toru ; Ohkuma, Hiroki
概要:
Neurologia medico chirurgica(日本脳神経外科学会)掲載論文。J-STAGEより本文転載。
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44.
学位論文 |
Saito, Junichi ; Ishihara, Hironori ; Hashiba, Eiji ; Okawa, Hirobumi ; Kudo, Tomoyuki ; Sawada, Masahiro ; Tsubo, Toshihito ; Hirota, Kazuyoshi
概要:
雑誌掲載本文:http://link.springer.com/article/10.1007/s00540-013-1558-z
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45.
学位論文 |
Yaegashi, Yukoh ; Satoh, Atsuko ; Kudoh, Hideaki ; Lee, Sangun ; Kitamiy, Chiaki ; Butler, James P. ; Sasaki, Hidetada
概要:
Aim: To compare diets between obese and non-obese in healthy older subjects. Methods: Forty-five obese and eighty-seven non-obese older subjects were recruited and their habitual factors that may contribute to obesity were
…
assessed. Intakes of food by food-group in the obesity and non-obesity groups were checked using a visual type presentation of model nutriational balance chart (MNBC). Results: Average intake ratio of food relative to ideal food intake was significantly higher in the obesity group than the non-obesity group. The relationship of obesity and exercise or habitual activities was not significant. Conclusion: Food intake is a primary factor of obesity but regular exercise or habitual activities is not a key factor for obesity in older subjects. Since exercise habit is difficult to achieve in older subjects, particularly those who are obese, food control using the present visualtype MNBC would be one strategy forthe management of obesity.<br />Open Access Journal
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46.
学位論文 |
Naraoka, Masato ; Munakata, Akira ; Matsuda, Naoya ; Shimamura, Norihito ; Ohkuma, Hiroki
概要:
The Rho/Rho-kinase pathway is considered important in the pathogenesis of sustained smooth muscle cell contraction durin
…
g cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). The aims of this study were to investigate whether combination treatment, with pitavastatin as an inhibitor of RhoA and fasudil as an inhibitor of Rho-kinase, prevents the cerebral vasospasm. SAH was simulated using the double-hemorrhage rabbit model, and pitavastatin, or fasudil, or both (combination treatment) were administrated. The basilar artery (BA) cross-sectional area only in the combination treatment group was statistically larger than in the SAH group (p < 0.05). BA Rho-kinase, as measured by ELISA, was statistically reduced only in the combination treatment group compared with the SAH group (p < 0.05). In the other two treatment groups, pitavastatin or fasudil treatment group showed larger BA cross-sectional areas and lower value for BA Rho-kinase, but there were no statistically significant differences compared with the SAH group. The expression of endothelial nitric oxide synthase (eNOS), evaluated by immunohistochemistry in the pitavastatin group and the combination group, was higher than in the SAH group. Results indicate that combination treatment could extensively prevent cerebral vasospasm due to the synergic effect of combining pitavastatin and fasudil on the Rho/Rho-kinase pathway and on eNOS.<br />Open Access Article
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47.
学位論文 |
Kudou, Hisashi ; Yaegaki, Makoto ; Takahashi, Ippei ; Umeda, Takashi ; Sawada, Kaori ; Okubo, Noriyuki ; Yamamoto, Yousuke ; Nakaji, Shigeyuki
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48.
学位論文 |
Nagaki, Takahiko ; Kakehata, Seiji ; Kitani, Rei ; Abe, Takahisa ; Shinkawa, Hideichi
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49.
学位論文 |
Maniwa, Keiichiro ; Ishibashi, Yasuyuki ; Yamamoto, Yuji ; Inoue, Ryo ; Otsuka, Hironori
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50.
学位論文 |
Chin, Shunfu ; Furukawa, Ken-Ichi ; Ono, Atsushi ; Asari, Toru ; Harada, Yoshifumi ; Wada, Kanichiro ; Tanaka, Toshihiro ; Inaba, Wataru ; Mizukami, Hiroki ; Motomura, Shigeru ; Yagihashi, Soroku ; Ishibashi, Yasuyuki
概要:
Mesenchymal stem cells (MSCs) have been isolated from various tissues and used for elucidating the pathogenesis of numer
…
ous diseases. In our previous in vitro study, we showed the existence of MSCs in human spinal ligaments and hypothesized that these MSCs contributed to the pathogenesis of ossification of spinal ligaments. The purpose of this study was to use immunohistochemical techniques to analyze the localization of MSCs in ossified human spinal ligaments in situ. Ossified (OLF) or non-ossified ligamentum flavum (non-OLF) samples from the thoracic vertebra were obtained from patients who had undergone posterior spinal surgery. Serial sections were prepared from paraffin-embedded samples, and double immunofluorescence staining was performed using antibodies against markers for MSCs (CD73, CD90 and CD105), endothelial cells (CD31), pericytes (α-smooth muscle actin), and chondrocytes (S100). Immunolocalization of MSCs was observed in the perivascular area and collagenous matrix in spinal ligaments. Markers for MSCs and pericytes were co-expressed in the perivascular area. Compared with non-OLF, OLF had a large amount of neovascularization in the fragmented ligament matrix, and a high accumulation of MSCs around blood vessels. The prevalence of MSCs in OLF within collagenous matrix was significantly higher than that in non-OLF. Chondrocytes near the ossification front in OLF also presented expression of MSC markers. MSCs may contribute to the ectopic ossification process of OLF through endochondral ossification.
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51.
学位論文 |
Sasaki, Eiji ; Ishibashi, Yasuyuki ; Tsuda, Eiichi ; Ono, Atsushi ; Yamamoto, Yuji ; Inoue, Ryo ; Takahashi, Ippei ; Umeda, Takashi ; Nakaji, Shigeyuki
概要:
論文の全文は掲載不可
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52.
学位論文 |
Murakami, Hiroshi ; Tanabe, Jutaro ; Tamasawa, Naoki ; Matsumura, Koki ; Yamashita, Maki ; Matsuki, Kota ; Matsui, Jun ; Suda, Toshihiro
概要:
博士論文の本文は掲載不可
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53.
学位論文 |
前田, 周吾
概要:
出版社版本文リンクhttp://www.sciencedirect.com/science/article/pii/S0749806311003665
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54.
学位論文 |
Hashimoto, Kojiro
概要:
出版社版リンクhttp://www.dovepress.com/getfile.php?fileID=22147
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55.
学位論文 |
Sakuraba, Shingo
概要:
弘前医学66(1)2015、p.28-37に掲載
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56.
学位論文 |
Sato, Mariko
概要:
出版社版本文リンクMolecular Medicine Reports 12(3),2015http://www.spandidos-publications.com/mmr/12/3/3462
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57.
学位論文 |
Osawa, Yuki
概要:
出版社版本文リンクhttp://www.spandidos-publications.com/ijo/46/3/1252
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58.
学位論文 |
Tamura, Ryosuke
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59.
学位論文 |
Matsushita, Yoko
概要:
出版社版本文リンクhttp://www.ovarianresearch.com/content/7/1/107
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60.
学位論文 |
Matsumura, Yukiko
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61.
学位論文 |
Murakami, Kazuo
概要:
冠攣縮性狭心症患者の皮膚線維芽細胞においてphospholipase C(PLC)-δ1活性は亢進しており、PLC-δ1過剰発現マウスでは冠攣縮が誘発されることを報告した。今回我々はPLC-δ1過剰発現下で、アセチルコリン誘発性カルシウム流
…
入におけるprotein kinase C(PKC)の役割についてhuman embryonic kidney 293細胞を用いて検討した。アセチルコリン誘発性カルシウム流入はPLC-δ1過剰発現並びにPKCの抑制により優位に増加し,PKCの活性化により減少した。ニフェジピン存在下でのアセチルコリン誘発性カルシウム流入もPLC-δ1過剰発現並びにPKCの抑制により増加した。PKCはアセチルコリン誘発性カルシウム流入に対して負に作用し,ニフェジピン投与の影響をほとんど受けないことが示唆された。<br />http://repository.ul.hirosaki-u.ac.jp/dspace/handle/10129/5559
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62.
学位論文 |
Okubo, Noriyuki
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63.
学位論文 |
Wada, Naoko
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64.
学位論文 |
Tsuruga, Koji
概要:
出版社版本文リンクhttp://www.dovepress.com/getfile.php?fileID=24755
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65.
学位論文 |
清野, 浩子
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66.
学位論文 |
稲葉, 渉
概要:
出版社版本文リンクhttp://www.sciencedirect.com/science/article/pii/S0014299912006243
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67.
学位論文 |
杉山, 綾
概要:
出版社版本文リンクhttp://link.springer.com/article/10.1007%2Fs11102-014-0607-4
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68.
学位論文 |
松村, 功貴
概要:
出版社版本文リンクhttp://dx.doi.org/10.1007/s13340-014-0200-0
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69.
学位論文 |
村澤, 真吾
概要:
出版社版本文リンクhttp://www.sciencedirect.com/science/article/pii/S0303720714002056
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70.
学位論文 |
吉澤, 佳織
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71.
学位論文 |
漆坂, 真弓
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72.
学位論文 |
和田, 盛人
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73.
学位論文 |
叶, 鵬
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74.
学位論文 |
石橋, 祐介
概要:
出版社版本文リンクhttp://onlinelibrary.wiley.com/doi/10.1002/pros.22869/abstract
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75.
学位論文 |
Kamata, Kosuke ; Mizukami, Hiroki ; Inaba, Wataru ; Tsuboi, Kentaro ; Tateishi, Yoshinori ; Yoshida, Taro ; Yagihashi, Soroku
概要:
Aims: Islet amyloid is a hallmark in type 2 diabetic subjects, but its implication in clinical features and development of islet pathology is still unclear.Methods: From 118 autopsy cases with type 2 diabetes, 26 cases with
…
islet amyloid deposition (DA+) were selected. Twenty diabetic subjects without obvious amyloid deposition (DA ) matched for the age and diabetes duration and 20 non-diabetic subjects (ND) served for comparison. We examined the severity of amyloid deposition and its relationships with population of endocrine cells, expression of cell damage markers or macrophage infiltration. Correlation of clinical profile with islet pathology was also sought on the subset of the investigated patients.Results: b-Cell volume density was nearly 40% less in DA+ and 20% less in DA when compared to ND. Severity of amyloid deposition correlated with reduced volume densities of b-cell and a-cell, and increased body mass index (BMI), but not with duration of diabetes, age or HbA1c. Amyloid-rich islets contained an increased number of macrophages mixed with b-cells with oxidative stress-related DNA damage, characterized by gH2AX expression, and suppressed (pro)insulin mRNA expression.Conclusions: In Japanese type 2 diabetic patients, islet amyloid was more common with severe b-cell loss and high BMI, associated with macrophage infiltration.
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76.
学位論文 |
Mastuda, Naoya
概要:
掲載誌本文:http://thejns.org/doi/abs/10.3171/2014.5.JNS132140
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77.
学位論文 |
Isamu, Hanada
概要:
出版社版本文:http://onlinelibrary.wiley.com/doi/10.1002/gcc.22201/abstract
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78.
学位論文 |
Yoshizawa, Tadashi
概要:
Invasive micropapillary carcinoma (IMPC) was originally described as a distinctive type of invasive carcinoma in the bre
…
ast, but it has not been recognized as a histological type of the extrahepatic bile duct cancer. The present study demonstrated clinicopathological features and patient prognosis of IMPC. We examined histological reviews of 93 consecutive cases of the extrahepatic bile duct cancer and identified 13 cases which included IMPC component. The component of IMPC ranged from 5 to 60% of the primary tumor tissue, which was mainly detected at the invasive front of the tumor. Of the 13 cases, 12 (92.3%) carcinomas with IMPC showed lymph node metastasis more frequently compared to conventional adenocarcinoma (39.2%, P<0.001). Presence of IMPC component was significantly associated with poor overall survival (P=0.003). In conclusion, extrahepatic bile duct carcinoma with IMPC component showed significant lymphatic invasion, lymph node metastasis, and resulted in poor prognosis.<br />本文リンク:http://www.spandidos-publications.com/or/32/4/1355
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79.
学位論文 |
Yoneyama, Mihoko
概要:
To investigate the molecular mechanisms of cancer metastasis, we have isolated a high-metastatic bladder cancer cell sub
…
population from a low-metastatic cell line by using an in vivo selection system. Cells in the subpopulation showed a high ability to form invadopodia, the filamentous actin (F-actin)-based membrane protrusions that play an essential role in cancer cell invasion. Analysis of the gene expression profile revealed that the expression of an intermediate filament (IF) protein, vimentin and a cytoskeletal linker protein, plectin was up-regulated in the high-metastatic subpopulation compared with the low metastatic cell line. Here we report a novel role of vimentin IF and plectin in metastasis. In invasive bladder cancer cells, the vimentin IF-plectin-invadopodia F-actin link was formed. Disruption of this link severely impaired invadopodia formation, reducing the capacities of extracellular matrix degradation, transendothelial migration and metastasis. In addition, the vimentin assembly into the filaments was required for invadopodia formation. Our results suggest that plectin anchoring invadopodia to vimentin IF scaffolds and stabilizes invadopodia, which is a critical molecular process for cancer cell invasion and extravasation for metastasis.<br />掲載誌本文リンク:http://www.sciencedirect.com/science/article/pii/S017193351400048X
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80.
学位論文 |
Yoshimura, Sayuri
概要:
Rheumatoid arthritis (RA) is a serious autoimmune disease caused by chronic inflammation of connective tissues. The basi
…
c principle of RA treatment is aimed to reduce joint inflammation. Our previous studies demonstrated that salmon cartilage proteoglycan (PG) suppresses excess inflammation in different mouse inflammatory diseases. In this study, we investigated the prophylactic effect of PG on the progression of RA using an experimental mouse model, collagen-induced arthritis (CIA). Clinical and histological severity of CIA was attenuated by daily oral administration of PG. In the joints of PG-administered mice, infiltration of macrophages and neutrophils and also osteoclast accumulation were limited. In comparison to nonadministered mice, anti-collagen antibodies in the sera of PG-administered mice did not alter. On the other hand, local expression of interleukin-17A (IL-17A), IL-6, IL-1β, interferon-γ (IFN-γ), C-C chemokine ligand 2 (CCL2), C-X-C chemokine ligand 1 (CXCL1), and CXCL2 in the joints of PG-administered mice decreased. Moreover, in the response of type II collagen- (CII-) restimulation ex vivo, IL-17A and IFN-γ production by splenocytes from PG-administered mice was less than that of control mice. These data suggested that daily ingested PG attenuated CIA pathogenesis by modulating immune response of splenocytes to CII stimulation and local production inflammatory cytokines and chemokines in the joints.<br />掲載誌本文:http://www.hindawi.com/journals/bmri/2014/406453/
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81.
学位論文 |
Sasaki, Ayako
概要:
掲載誌Human Cell, 29(1), p.37-45, 2016\nhttp://link.springer.com/article/10.1007/s13577-015-0125-3
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82.
学位論文 |
Kudo, Syuhei
概要:
掲載誌Neuropsychiatric Disease and Treatment, 2015(11), p.2811-2816, 2015http://dx.doi.org/10.2147/NDT.S93657
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83.
学位論文 |
Haga, Toshihiro
概要:
掲載誌弘前医学, 67(1), p.28-38, 2016
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84.
学位論文 |
Hirai, Hideaki
概要:
掲載誌Biomedical Research (Tokyo), 37(2), p.77-84, 2016http://doi.org/10.2220/biomedres.37.77
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85.
学位論文 |
Yoshida, Eri
概要:
掲載誌Oncology Letters, 12(4), 2337-2344, 2016
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86.
学位論文 |
Kojima, Yuta
概要:
掲載誌PLoS ONE, Sep. 21, 2015http://dx.doi.org/10.1371/journal.pone.0138520
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87.
学位論文 |
Fujita, Naoki
概要:
掲載誌International Journal of Urology, 23(5), p.412-417, 2016http://onlinelibrary.wiley.com/doi/10.1111/iju.13060/abstract
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88.
学位論文 |
Kobayashi, Asami
概要:
掲載誌Cancer Gene Therapy, 23, p.24-28, 2016http://www.nature.com/cgt/journal/v23/n1/full/cgt201561a.html
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89.
学位論文 |
Miura, Rie
概要:
掲載誌International Journal of Oncology, 47(6), p.2173-2180, 2015https://www.spandidos-publications.com/ijo/47/6/2173?text=fulltext
|
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90.
学位論文 |
Mizunuma, Makito
概要:
掲載誌International Journal of Clinical Oncology, 20(5), p.989-996, 2015http://link.springer.com/article/10.1007%2Fs10147-015-0807-6
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91.
学位論文 |
Chiba, Daisuke
概要:
掲載誌Journal of Bone and Mineral Metabolism, 35(1), p.65-72, 2017
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92.
学位論文 |
Oishi, Kazuki
概要:
掲載誌The Knee, 23(1), p.35-42, 2016
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93.
学位論文 |
Iwamura, Hiromichi
概要:
掲載誌BMC Urology, 201515:120, 2015
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94.
学位論文 |
Sato, Tendo
概要:
掲載誌Biochemical and Biophysical Research Communications, 170(1), p.150-156, 2016http://www.sciencedirect.com/science/article/pii/S0006291X16300110
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95.
学位論文 |
Mikami, Jotaro
概要:
掲載誌Cancer Science, 107(3), p.359-368, 2015http://onlinelibrary.wiley.com/doi/10.1111/cas.12859/abstract
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96.
学位論文 |
Sato, Satoshi
概要:
掲載誌:弘前医学, 67(1), 13-27, 2016
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97.
学位論文 |
Sawada, Naoya
概要:
掲載誌弘前医学, 66(2-4), p.143-151, 2016
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98.
学位論文 |
Yoshida, Kenta
概要:
掲載誌弘前医学, 66(2-4), p.152-161, 2016
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99.
学位論文 |
Narita, Ikuyo
概要:
掲載誌Clinical and Experimental Nephrology, 20(5), p.679-688, 2016
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100.
学位論文 |
Kimura, Yuki
概要:
掲載誌弘前医学, 65(1), 2014, p.35-42
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