Changes of Proteoglycan Expression and Glycosaminoglycan Constituents in the Intervillous Space of the Pregnancy-Induced Hypertension Placenta

フォーマット:

論文

責任表示:

Matsukura, Daisuke ; Yokoyama, Yoshihito ; Tanaka, Kanji ; Ozaki, Takashi ; Mizunuma, Hideki

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2008-03-31

著者名:

• Matsukura, Daisuke
• Yokoyama, Yoshihito
• Tanaka, Kanji
• Ozaki, Takashi
• Mizunuma, Hideki

掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

59

通号:

2/3/4

開始ページ:

128

終了ページ:

135

バージョン:

publisher

概要:

The changes in proteoglycan (PG) expression and glycosaminoglycan (GAG) constituents in the intervillous space of the pregnancy-induced hypertension (PIR) placenta were investigated. PGs and GAGs were purified from the extract of the placental intervillous space by the DEAE-Sephacel column and salt-concentration gradient method. and the GAG sugar chains were released by the actinase and cellulase treatments. The sugar chains from the placentas of … normal pregnancy and PIR were compared by cellulose-acetate membrane electrophoresis. No difference was observed in the expressions of hyaluronic acid. heparan sulfate, and chondroitin sulfate. but a clear increase in the expression of dermatan sulfate (DS) in the placenta of the PIR was confirmed. An increase of the DS that specifically activates anticoagulants can be a body reaction to counteract the hemostatic condition observed in PIR. 続きを見る

URL:

http://hdl.handle.net/10129/706