Two Contradictory Roles of Hyaluronan in an Experimental Rat Acute Pancreatitis Model

フォーマット:

論文

責任表示:

Igarashi, Go ; Sawada, Naoya ; Kimura, Masayo ; Endo, Tetsu ; Fukuda, Shinsaku

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2017-10-05

著者名:

• Igarashi, Go
• Sawada, Naoya
• Kimura, Masayo
• Endo, Tetsu
• Fukuda, Shinsaku

掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

68

通号:

1

開始ページ:

62

終了ページ:

70

バージョン:

publisher

概要:

Hyaluronan plays a role not only as a structural component but also in theregulation of inflammatory processes. However, the role of hyaluronan in acute pancreatitis is not clear. In this study,we have explored the role of hyaluronan in a r … at acute pancreatitis model using a hyaluronan synthesis inhibitor,4-methylumbelliferone（ 4-MU）. Methods: Six-week-old male Sprague-Dawley rats were fed a standard diet or the samediet containing 5% 4-MU beginning two weeks before induction of cerulean- and lipopolysaccharide-induced acutepancreatitis. The severity of acute pancreatitis and pro-inflammatory cytokine levels were evaluated with or withoutpretreatment with 4-MU. Results: Before development of acute pancreatitis, 4-MU pretreatment reduced serumhyaluronan levels. After development of acute pancreatitis, 4-MU pretreatment increased serum amylase level and bloodurea nitrogen/creatinine ratio. However, 4-MU pretreatment suppressed tumor necrosis factor-α （TNF- α） production inacute pancreatitis. Conclusions: Systemic inhibition of hyaluronan exacerbated acute pancreatitis in spite of suppressionof TNF-α production. These data suggest that hyaluronan has two completely different effects, i.e., a barrier functionand as a regulator of inflammation in acute pancreatitis. The results emphasize that further analysis that takes into account the molecular size of hyaluronan is needed since it may explain the contradictory findings. 続きを見る

URL:

http://hdl.handle.net/10129/6149