Effects of Enflurane on Cardiac Autonomic Nervous Activity in Mice

フォーマット:

論文

責任表示:

Ogata, Yoshiki ; Yonekura, Manabu ; Yamaki, Rouichi ; Han, Chong ; Fujiwara, Tomonori ; Seya, Kazuhiko ; Niwa, Hidetoshi ; Kushikata, Tetsuya ; Imaizumi, Tadaatsu ; Hirota, Kazuyoshi ; Tomita, Hirofumi ; Murakami, Manabu

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2017-02-27

著者名:

Ogata, Yoshiki

Yonekura, Manabu

Yamaki, Rouichi

Han, Chong

Fujiwara, Tomonori

Seya, Kazuhiko

Niwa, Hidetoshi

Kushikata, Tetsuya

Imaizumi, Tadaatsu

Hirota, Kazuyoshi

Tomita, Hirofumi

Murakami, Manabu

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掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

67

通号:

2-4

開始ページ:

153

終了ページ:

157

バージョン:

publisher

概要:

We examined the effects of enflurane anesthesia on the mouse cardiac autonomic nervous system usingelectrocardiogram（ ECG） analysis. Enflurane had a lower effect on heart rate（ HR） compared to isoflurane, which ismore widely used in small a … nimal studies. Under anesthesia with 3 or 4% of enflurane, administration of propranololhad a significant effect on HR. Enflurane increased R-R interval length in a dose-dependent fashion, and the R-Rinterval became unstable at high concentrations. Although HR decreased with high doses of enflurane, we observednormal sinus rhythm and no arrhythmia. These results suggest that the effect of enflurane anesthesia is acceptableeven though the drug can lead to cardiac instability. No remarkable changes were observed in HR frequency. These results suggest that enflurane anesthesia may be suitable for cardiac autonomic nervous system analysis. 続きを見る

URL:

http://hdl.handle.net/10129/6015