Effects of Halothane Anesthesia on Electrocardiogram Parameters in Mice

フォーマット:

論文

責任表示:

Nozaki, Shuhei ; Ogata, Yoshiki ; Yonekura, Manabu ; Han, Chong ; Niwa, Hidetoshi ; Kushikata, Tetsuya ; Hirota, Kazuyoshi ; Matsuzaki, Yasushi ; Tomita, Hirofumi ; Imaizumi, Tadaatsu ; Itagaki, Shirou ; Sawamura, Daisuke ; Murakami, Manabu

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2017-02-27

著者名:

Nozaki, Shuhei

Ogata, Yoshiki

Yonekura, Manabu

Han, Chong

Niwa, Hidetoshi

Kushikata, Tetsuya

Hirota, Kazuyoshi

Matsuzaki, Yasushi

Tomita, Hirofumi

Imaizumi, Tadaatsu

Itagaki, Shirou

Sawamura, Daisuke

Murakami, Manabu

続きを見る

掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

67

通号:

2-4

開始ページ:

129

終了ページ:

135

バージョン:

publisher

概要:

We analyzed the effects of halothane as an inhalational anesthetic agent on electrocardiogram （ECG）parameters in C57/BL6 mice. Following induction of anesthesia using 2% halothane, the ECGs showed a regularpattern and the heart rate （HR） wa … s within an acceptable range （~500 bpm）. The HR decreased with increasinghalothane concentration in a concentration-dependent fashion.　 The frequency domain analysis showed that the high-frequency （HF） component decreased and the lowfrequency（LF） component increased in a concentration-dependent fashion. Therefore, the LF/HF ratio increasedwith increasing halothane concentration, suggesting effects on the autonomic nervous system.　 We analyzed the pharmacological response to sympathetic blockade with propranolol, a typical adrenergicβ-blocker, under halothane anesthesia. Propranolol administration resulted in a decreased HR; interestingly,intraperitoneal injection of propranolol （120 μg/kg body weight） resulted in arrhythmia （sick sinus syndrome）during anesthesia with 3% halothane.　Our results indicate the importance of selecting a suitable anesthetic agent for C57/BL6 mice in pharmacological studies 続きを見る

URL:

http://hdl.handle.net/10129/6012