Influence of Trace Elements within Normal Physiological Range on Neutrophil Basal Reactive Oxygen Species Production in the Japanese General Population

フォーマット:

論文

責任表示:

Ito, Haruyuki ; Takahashi, Ippei ; Matsuzaka, Masashi ; Lee, Sangun ; Itai, Kazuyoshi ; Fukui, Shinji ; Hamada, Naoko ; Saito, Yuriko ; Umeda, Takashi ; Nakaji, Shigeyuki

言語:

日本語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2012-11-30

著者名:

Ito, Haruyuki

Takahashi, Ippei

Matsuzaka, Masashi

Lee, Sangun

Itai, Kazuyoshi

Fukui, Shinji

Hamada, Naoko

Saito, Yuriko

Umeda, Takashi

Nakaji, Shigeyuki

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掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

63

通号:

2-4

開始ページ:

85

終了ページ:

95

バージョン:

publisher

概要:

Objective: We investigated the relationship between trace element concentrations and neutrophil basalreactive oxygen species（ ROS） production capability among the Japanese general population.　 Subjects and methods: Subjects of the current s … tudy were 606 participants（ 225 males and 381 females） who had participated in the Iwaki Health Promotion Project 2005. Body mass index, biochemical blood examination, neutrophilbasal ROS production and serum concentrations of trace element （Copper（Cu）, Zinc（Zn）, Iron（Fe）, Selenium（Se）） were measured. Each trace element was divided into 4 quartiles according to the concentration, and theneutrophil basal ROS production of each group was compared and analyzed. Moreover, the relationship between the concentration and neutrophil basal ROS production capability was assessed using a multiple linear regression analysis.　 Results: For both males and females, a tendency to low neutrophil ROS production associated with higher Se serum concentration was observed. On the other hand, no significant correlation was observed between the Cu, Zn and Fe concentrations and neutrophil basal ROS production capability.　 Conclusion: In conclusion, serum Se relieves oxidative stress through inhibiting neutrophil ROS production within a physiological range. On the other hand, our results suggested that neutrophil ROS production was unaffected by Cu, Zn and Fe concentrations within the normal physiological range. 続きを見る

URL:

http://hdl.handle.net/10129/4810