Possible Function of Neuronal Leucine-Rich Repeat Protein 3( NLRR3) in Primary Immune Response
- フォーマット:
- 論文
- 責任表示:
- Ito, Kyoko ; Masuko, Kazutaka ; Ito, Koichi
- 言語:
- 英語
- 出版情報:
- 弘前大学出版会, 2010-03-25
- 著者名:
- 掲載情報:
- 弘前医学
- ISSN:
- 0439-1721
- 巻:
- 61
- 通号:
- 1
- 開始ページ:
- 46
- 終了ページ:
- 57
- バージョン:
- publisher
- 概要:
- Contact between dendritic cells( DCs) and resting T cells is essential for initiation of the primary immuneresponse. In this study, we examined whether neuronal leucine-rich repeat protein 3 (NLRR3), a receptor involvedin nerve system devel … opment, participates in DC-T cell binding and T-cell activation. We confirmed that NLRR3is expressed on naive T cells. NLRR3 contains an Arg-Gly-Asp (RGD) motif in its amino acid sequence, for whichseveral integrins can be considered as potential ligands. Indeed, monocyte-derived DCs expressed several integrinsthat can bind to the RGD motif. Functionally, DC-induced resting allogeneic T-cell proliferation was partially inhibitedby addition of integrin-specific antibodies and synthetic RGD peptides, indicating that RGD-containing molecules,including NLRR3 and several integrins, at least participate in the events of the initial primary immune responseinvolving naive T cells and DCs. Furthermore, DCs were shown to bind directly to NLRR3-transfected Chinesehamster ovary cells in a NLRR3-dependent manner, and the binding was removed in the presence of integrin-specifi cantibodies. These data suggest that NLRR3 plays an important role in initiation of the primary immune response. 続きを見る
- URL:
- http://hdl.handle.net/10129/3279
類似資料:
弘前大学大学院医学研究科・弘前医学会 | |
弘前大学大学院医学研究科・弘前医学会 |
三修社 |
弘前大学大学院医学研究科・弘前医学会 |
New Science Press, Blackwell, Sinauer Associates |
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Cold Spring Harbor Laboratory |
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