All-trans-retinoic acid (atRA) increases host resistance to Listeria monocytogenes infection

フォーマット:

論文

責任表示:

Hiraga, Hiroto ; Sashinami, Hiroshi ; Hu, Dong-Liang ; Ishiguro, Yoh ; Wakabayashi, Koichi ; Munakata, Akihiro ; Nakane, Akio

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2007-11-29

著者名:

Hiraga, Hiroto

Sashinami, Hiroshi

Hu, Dong-Liang

Ishiguro, Yoh

Wakabayashi, Koichi

Munakata, Akihiro

Nakane, Akio

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掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

59

通号:

Supplement

開始ページ:

S244

終了ページ:

S252

バージョン:

publisher

概要:

Dietary vitamin A is an essential precursor of tissue retinol, which participates in a variety of biological processes including innate immunity. Functions of vitamin A mainly depend on retinoic acid（ RA）, principally all-trans- RA （atRA） … and 9-cis-RA. We assessed whether atRA is benefi cial in host resistance against bacterial infections or not. Vitamin A-defi cient（ VAD） mice were highly susceptible to infection with Listeria monocytogenes. Pre-treatment with atRA enhanced host resistance against L. monocytogenes infection in both VAD and VAS mice. Interferon（ IFN） -γ production in atRA pre-treated VAS mice was not higher compared with the control VAD mice. The eff ect of atRA was independent of T cells and B cells. The bactericidal activity in macrophages obtained from atRA pre-treated VAS mice was almost the same level compared with the control VAS mice. Our results demonstrated that the treatment with atRA is benefi cial for host resistance against L. monocytogenes infection in the early phase and suggested a new therapeutic possibility of atRA in bacterial infections. 続きを見る

URL:

http://hdl.handle.net/10129/2242