Staphylococcal enterotoxin a modulates intracellular Ca^2+ signal pathway in human intestinal epithelial cells
- フォーマット:
- 論文
- 責任表示:
- Hu, Dong-Liang ; Suga, Yochiko ; Omoe, Katsuhiko ; Abe, Yoshinao ; Shinagawa, Kunihiro ; Wakui, Makoto ; Nakane, Akio
- 言語:
- 英語
- 出版情報:
- 弘前大学大学院医学研究科・弘前医学会, 2007-11-29
- 著者名:
Hu, Dong-Liang Suga, Yochiko Omoe, Katsuhiko Abe, Yoshinao Shinagawa, Kunihiro Wakui, Makoto Nakane, Akio - 掲載情報:
- 弘前医学
- ISSN:
- 0439-1721
- 巻:
- 59
- 通号:
- Supplement
- 開始ページ:
- S219
- 終了ページ:
- S226
- バージョン:
- publisher
- 概要:
- To clarify whether SEA can aff ect any changes of cellular signalling pathways in intestinal epithelial cells, weperformed experiments to see if SEA can modulate the intracellular signaling pathway in intestinal epithelial cells. Wedemonstr … ate here that SEA induces an increase in intracellular calcium( [Ca2+]i) in human intestinal epithelial cells andthe[ Ca2+]i is released from intracellular stores. SEA-induced increase of[ Ca2+]i was clearly inhibited by treatment witha nitric oxide synthase( NOS) inhibitor, NG-monomethyl-L-arginine. Intestinal epithelial cells express endothelial NOS(eNOS) in resting cell condition, and express inducible NOS( iNOS) after stimulating with tumor necrosis factor( TNF)-α. TNF-α-pretreated cells showed a signifi cant increase in[ Ca2+]i that was also inhibited by the NOS inhibitor. Theseresults demonstrate that SEA induces an increase in intracellular Ca2+ concentration in human intestinal epithelial cells,and the expressions of both eNOS and iNOS could be responsible for the increase in intracellular Ca2+ concentration inthe cells induced by SEA. It is important to study the relationship of NOS expression, Ca2+ signal pathway and emesisfor understanding the mechanism of SEA-induced food poisoning. 続きを見る
- URL:
- http://hdl.handle.net/10129/2239
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弘前大学大学院医学研究科・弘前医学会 |
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