Effects of proinfl ammatory cytokines on intracellular glucocorticoid metabolism

フォーマット:

論文

責任表示:

Iwasaki, Yasumasa ; Tsugita, Makoto ; Taniguchi, Yoshimori ; Nigawara, Takeshi ; Takayasu, Shinobu ; Kawahara, Masayuki ; Suda, Toshihiro ; Hashimoto, Kozo

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2007-11-29

著者名:

Iwasaki, Yasumasa

Tsugita, Makoto

Taniguchi, Yoshimori

Nigawara, Takeshi

Takayasu, Shinobu

Kawahara, Masayuki

Suda, Toshihiro

Hashimoto, Kozo

続きを見る

掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

59

通号:

Supplement

開始ページ:

S58

終了ページ:

S61

バージョン:

publisher

概要:

Cytokines is known to infl uence hormone synthesis and secretion. Indeed, some of the proinfl ammatorycytokines stimulate hormone release at the hypothalamic, pituitary, and peripheral endocrine organs. Recently, a newparadigm of immune-end … ocrine interaction has been emerging. We and others have shown that cytokines modify theeff ectiveness of hormone action. This is occurring via enhancement of receptor-mediated signaling, or modifi cation ofintracellular metabolism of hormones. In the latter case, we found that representative cytokines such as interleukin 1βand TNFα stimulate the expression of the glucocorticoid-activating enzyme 11β- ~ hydroxysteroid dehydrogenase type1（ 11βHSD1） and suppress that of the inactivating enzyme 11βHSD2, thus increasing the intracellular concentrationand action of glucocorticoids. In vascular smooth muscle cells, this mechanism is advantageous in preventing vascularcollapse during sepsis. We also found that, in hepatocytes, cytokines suppress the expression of the thyroid hormoneactivatingenzyme 5’-deiodinase type I. This may be responsible for the low T3 syndrome in critical illness. 続きを見る

URL:

http://hdl.handle.net/10129/2217