IL-15-dependent cross-talk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
- フォーマット:
- 論文
- 責任表示:
- Ohteki, Toshiaki ; Kuwajima, Seiichi
- 言語:
- 英語
- 出版情報:
- 弘前大学大学院医学研究科・弘前医学会, 2007-11-29
- 著者名:
- 掲載情報:
- 弘前医学
- ISSN:
- 0439-1721
- 巻:
- 59
- 通号:
- Supplement
- 開始ページ:
- S35
- 終了ページ:
- S42
- バージョン:
- publisher
- 概要:
- Unmethylated CpG oligodeoxynucleotides (CpG) prevalent in bacteria and DNA viruses bind Toll-likereceptor( TLR) 9 and directly stimulate DCs, thereby activating the innate and adaptive immune responses. CpG ispotentially a powerful reagent … for protective immunity against infection by a wide variety of pathogens, for cancerand allergy therapies, and for the development of prophylactic and therapeutic vaccines. Here we investigated therole of interleukin (IL)-15 in the activation of CpG-induced immune responses. We show that upon CpG-priming,both wild-type( WT) and NK cell-depleted WT mice produce interleukin( IL)-12 p70 and become resistant to a lethaldose of Listeria monocytogenes( LM), whereas IL-15-/- mice impair IL-12 p70 production and succumb to the infection.Notably, CpG-stimulated conventional dendritic cells (cDCs) are the major producer of both IL-15 and IL-12 p70,but cDCs do not produce IL-12 in the absence of plasmacytoid DCs( pDCs) in vivo. Importantly, cDC-derived IL-15induces CD40 expression on cDCs, which interacts with CD40 ligand on pDCs, leading to CD40 cross-linking and IL-12production. Collectively, these fi ndings show that IL-15-dependent cross-talk between cDCs and pDCs is essential forCpG-induced immune activation( recently published in Nat Immunol 2006;7:740-6) 続きを見る
- URL:
- http://hdl.handle.net/10129/2214
類似資料:
弘前大学大学院医学研究科・弘前医学会 |
弘前大学大学院医学研究科・弘前医学会 |
Okaze Medical Publisher |