Pineal Structures and Functions in Mammalian Body Mechanisms Coping with Exogenous and Endogenous Changes

フォーマット:

論文

責任表示:

Kachi, Takashi

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2007-11-29

著者名:

Kachi, Takashi  

掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

59

通号:

Suppl.

開始ページ:

S262

終了ページ:

S277

バージョン:

publisher

概要:

Various aspects of pineal structures and functions have been reviewed. mainly relating to our ownobservations and experiments. The pineal gland shows high amplitude circadian rhythms in cellular and metabolicactivities. which are changeable under various circumstances. The pineal hormone appears to participate in the body'sadaptive regulatory system mostly by cooperative and modulatory mechanisms. particularly in relation to environmentalchanges … including stress/invasion. timing of physiological processes including reproductive activities. and possiblyexogenous and endogenous pathological changes such as inflammatory disease and tumor. Pineal effects are variabledue to the sensitivity/state of target mechanisms. For example. the pinealectomy effects on adreno-medullary adrenalinecells were more evident in comparison with the 'sham-pinealectomy' group than the normal group, and the pinealectomyeffects on female reproductive activities were age-dependent. In any case, the pineal hormone retains physiologicalfunctions at least till middle age. Pineal actions are mainly inhibitory. but can be also stimulatory as shown in immuneregulatory mechanisms. It has long been known that big differences in pineal structures and functions exist betweenmammals and submammals and that mammals show characteristic development of the brain, autonomic nervous systemand unique style of reproduction including pregnancy and suckling. These and other related results seem to support ahypothetical view that the pineal hormone was involved in drastic reorganization of the regulatory system occurred inthe evolutional process from submammals to mammals and became participated in the system which regulates complexbody mechanisms in mammals. 続きを見る

URL:

http://hdl.handle.net/10129/1889