Impairment of Calcium-Activated Potassium Channels in Endothelium-Derived Hyperpolarizing Factor Responses in Spontaneously Hypertensive Rats

フォーマット:

論文

責任表示:

Hasegawa, Kazushi ; Oikawa, Koichi ; Yoshida, Ikko ; Ishizaka, Hiroshi ; Osanai, Tomohiro ; Motomura, Shigeru ; Okumura, Ken

言語:

英語

出版情報:

弘前大学大学院医学研究科・弘前医学会, 2009-03-31

著者名:

Hasegawa, Kazushi

Oikawa, Koichi

Yoshida, Ikko

Ishizaka, Hiroshi

Osanai, Tomohiro

Motomura, Shigeru

Okumura, Ken

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掲載情報:

弘前医学

ISSN:

0439-1721      

巻:

60

通号:

1/2/3/4

開始ページ:

86

終了ページ:

95

バージョン:

publisher

概要:

To examine the effect of chronic hypertension on endothelium-derived hyperpolarizing factor（ EDHF）responses, the hearts of Wistar-Kyoto rats（ WKY） and spontaneously hypertensive rats（ SHR） were isolated andperfused using Langendorff system … with constant perfusion pressure. Bradykinin increased coronary fl ow（ CF） dosedependentlyand this was not aff ected by NG-nitro-L-arginine methyl ester or indomethacin, indicating that bradykinin’seff ect on CF was not mediated by nitric oxide or prostacyclin but by EDHF. Bradykinin-induced CF increase was smallerin SHR than in WKY. Tetrabutylammonium（ a non-specific KCa channel blocker） abolished bradykinin-induced CFincrease in both rats. 1-Ethyl-2-benzimedazolinone（ 1-EBIO, an agonist of intermediate conductance KCa channel）-inducedincrease in CF was smaller in SHR than in WKY. 1,3-Dihydro-1-[2-hydroxy-5（- trifl uoromethyl） phenyl]-5（- trifl uoromethyl）-2H-benzimidazol-2-one（ NS1619, an agonist of large conductance KCa channel）-induced increase in CF did not differbetween SHR and WKY. In early stage of hypertension, there was no signifi cant diff erence between SHR and WKY inbradykinin- and 1-EBIO-induced increases in CF. In conclusion, EDHF response in coronary microcirculation is impairedin SHR due to dysfunction of intermediate-conductance calcium-activated potassium channels. 続きを見る

URL:

http://hdl.handle.net/10129/1801